This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for PDIA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDIA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDIA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,689,600–10,690,429 | 122.8 kb | Distal (>10kb) Multiome | 876 | |
| chr2:10,721,088–10,722,120 | 91.1 kb | Distal (>10kb) Multiome | 294 | |
| chr2:10,812,144–10,813,386 | 64 bp | At TSS Multiome | 759 | |
| chr2:10,814,599–10,814,968 | 1.8 kb | Proximal (<10kb) | 212 | |
| chr2:10,817,494–10,817,690 | 4.7 kb | Proximal (<10kb) | 85 | |
| chr2:10,832,144–10,832,980 | 19.7 kb | Distal (>10kb) Multiome | 442 | |
| chr2:10,835,087–10,835,827 | 22.7 kb | Distal (>10kb) Multiome | 476 | |
| chr2:10,843,892–10,844,424 | 31.4 kb | Distal (>10kb) Multiome | 146 | |
| chr2:10,849,882–10,851,025 | 37.5 kb | Distal (>10kb) Multiome | 128 | |
| chr2:10,873,608–10,874,413 | 61.3 kb | Distal (>10kb) Multiome | 91 | |
| chr2:10,909,746–10,910,391 | 97.2 kb | Distal (>10kb) Multiome | 127 | |
| chr2:10,910,935–10,912,648 | 98.8 kb | Distal (>10kb) Multiome | 421 | |
| chr2:11,129,508–11,130,490 | 317.3 kb | Distal (>10kb) Multiome HiCAR | 660 | |
| chr2:11,132,494–11,133,872 | 320.1 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr2:11,743,889–11,745,399 | 931.5 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr2:11,745,980–11,747,523 | 933.9 kb | Distal (>10kb) Multiome HiCAR | 809 |
Genomic view of the PDIA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.