Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC66A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC66A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC66A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,873,608–10,874,413 | 281.4 kb | Distal (>10kb) Multiome | 91 | |
| chr2:10,909,746–10,910,391 | 245.5 kb | Distal (>10kb) Multiome | 127 | |
| chr2:10,910,935–10,912,648 | 243.9 kb | Distal (>10kb) Multiome | 421 | |
| chr2:11,129,508–11,130,490 | 25.4 kb | Distal (>10kb) Multiome | 660 | |
| chr2:11,132,494–11,133,872 | 22.6 kb | Distal (>10kb) Multiome | 774 | |
| chr2:11,154,551–11,156,096 | 166 bp | At TSS Multiome | 845 | |
| chr2:11,343,518–11,345,475 | 189.3 kb | Distal (>10kb) Multiome | 1010 |
Genomic view of the SLC66A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.