This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for BHLHE22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BHLHE22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BHLHE22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:64,575,150–64,576,578 | 3.8 kb | Proximal (<10kb) | 212 | |
| chr8:64,577,016–64,578,817 | 1.5 kb | Proximal (<10kb) | 362 | |
| chr8:64,579,671–64,582,347 | at TSS | At TSS | 477 | |
| chr8:64,585,340–64,586,287 | 5.0 kb | Proximal (<10kb) | 47 | |
| chr8:64,586,989–64,587,617 | 6.6 kb | Proximal (<10kb) | 72 |
Genomic view of the BHLHE22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.