This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for ZNF687. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF687 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF687, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,981,212–150,981,672 | 300.9 kb | Distal (>10kb) Multiome | 379 | |
| chr1:151,006,389–151,007,024 | 275.5 kb | Distal (>10kb) Multiome | 496 | |
| chr1:151,008,116–151,008,852 | 273.8 kb | Distal (>10kb) Multiome | 763 | |
| chr1:151,047,405–151,048,764 | 233.7 kb | Distal (>10kb) Multiome | 714 | |
| chr1:151,059,187–151,059,842 | 222.7 kb | Distal (>10kb) Multiome | 821 | |
| chr1:151,060,204–151,060,723 | 221.8 kb | Distal (>10kb) Multiome | 346 | |
| chr1:151,070,369–151,071,463 | 211.2 kb | Distal (>10kb) Multiome | 835 | |
| chr1:151,131,105–151,132,256 | 150.8 kb | Distal (>10kb) Multiome | 247 | |
| chr1:151,145,115–151,147,333 | 135.5 kb | Distal (>10kb) Multiome | 709 | |
| chr1:151,165,133–151,166,350 | 116.4 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 92.1 kb | Distal (>10kb) Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 83.7 kb | Distal (>10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 27.5 kb | Distal (>10kb) Multiome | 770 | |
| chr1:151,281,008–151,283,557 | 926 bp | At TSS Multiome | 1121 | |
| chr1:151,327,019–151,328,343 | 45.4 kb | Distal (>10kb) Multiome | 719 | |
| chr1:151,346,796–151,347,793 | 65.0 kb | Distal (>10kb) Multiome | 711 | |
| chr1:151,399,359–151,400,043 | 117.2 kb | Distal (>10kb) Multiome | 776 | |
| chr1:151,458,247–151,459,879 | 177.1 kb | Distal (>10kb) Multiome | 796 | |
| chr1:151,491,747–151,492,512 | 209.9 kb | Distal (>10kb) Multiome | 146 | |
| chr1:151,502,459–151,503,303 | 220.6 kb | Distal (>10kb) Multiome | 99 | |
| chr1:151,510,863–151,512,136 | 229.1 kb | Distal (>10kb) Multiome | 640 | |
| chr1:151,539,661–151,541,320 | 258.0 kb | Distal (>10kb) Multiome | 830 |
Genomic view of the ZNF687 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.