This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP6V1C2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V1C2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V1C2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,432,300–10,432,926 | 289.0 kb | Distal (>10kb) Multiome | 273 | |
| chr2:10,434,743–10,435,398 | 286.5 kb | Distal (>10kb) Multiome | 526 | |
| chr2:10,447,433–10,449,378 | 273.1 kb | Distal (>10kb) Multiome | 1156 | |
| chr2:10,453,499–10,454,189 | 267.9 kb | Distal (>10kb) Multiome | 50 | |
| chr2:10,477,158–10,478,678 | 243.6 kb | Distal (>10kb) Multiome | 378 | |
| chr2:10,689,600–10,690,429 | 31.6 kb | Distal (>10kb) Multiome | 876 | |
| chr2:10,721,088–10,722,120 | 38 bp | At TSS Multiome | 294 | |
| chr2:10,812,144–10,813,386 | 91.2 kb | Distal (>10kb) Multiome | 759 | |
| chr2:10,832,144–10,832,980 | 110.9 kb | Distal (>10kb) Multiome | 442 | |
| chr2:10,835,087–10,835,827 | 113.8 kb | Distal (>10kb) Multiome | 476 | |
| chr2:10,843,892–10,844,424 | 122.6 kb | Distal (>10kb) Multiome | 146 | |
| chr2:10,849,882–10,851,025 | 128.7 kb | Distal (>10kb) Multiome | 128 | |
| chr2:10,873,608–10,874,413 | 152.4 kb | Distal (>10kb) Multiome | 91 | |
| chr2:10,909,746–10,910,391 | 188.4 kb | Distal (>10kb) Multiome | 127 | |
| chr2:10,910,935–10,912,648 | 189.9 kb | Distal (>10kb) Multiome | 421 |
Genomic view of the ATP6V1C2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.