Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOL10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOL10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOL10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,409,111–10,409,643 | 280.7 kb | Distal (>10kb) Multiome | 552 | |
| chr2:10,432,300–10,432,926 | 257.3 kb | Distal (>10kb) Multiome | 273 | |
| chr2:10,434,743–10,435,398 | 254.9 kb | Distal (>10kb) Multiome | 526 | |
| chr2:10,447,433–10,449,378 | 241.4 kb | Distal (>10kb) Multiome | 1156 | |
| chr2:10,453,499–10,454,189 | 236.2 kb | Distal (>10kb) Multiome | 50 | |
| chr2:10,477,158–10,478,678 | 211.9 kb | Distal (>10kb) Multiome | 378 | |
| chr2:10,689,600–10,690,429 | 53 bp | At TSS Multiome | 876 | |
| chr2:10,721,088–10,722,120 | 31.7 kb | Distal (>10kb) Multiome | 294 | |
| chr2:10,812,144–10,813,386 | 122.9 kb | Distal (>10kb) Multiome | 759 | |
| chr2:10,832,144–10,832,980 | 142.5 kb | Distal (>10kb) Multiome | 442 | |
| chr2:10,835,087–10,835,827 | 145.5 kb | Distal (>10kb) Multiome | 476 | |
| chr2:10,843,892–10,844,424 | 154.3 kb | Distal (>10kb) Multiome | 146 | |
| chr2:10,849,882–10,851,025 | 160.4 kb | Distal (>10kb) Multiome | 128 | |
| chr2:10,873,608–10,874,413 | 184.1 kb | Distal (>10kb) Multiome | 91 | |
| chr2:10,909,746–10,910,391 | 220.1 kb | Distal (>10kb) Multiome | 127 | |
| chr2:10,910,935–10,912,648 | 221.6 kb | Distal (>10kb) Multiome | 421 |
Genomic view of the NOL10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.