Located in cilium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C2orf50. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf50 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf50, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,812,144–10,813,386 | 320.3 kb | Distal (>10kb) Multiome HiCAR | 759 | |
| chr2:10,832,144–10,832,980 | 300.6 kb | Distal (>10kb) Multiome HiCAR | 442 | |
| chr2:10,835,087–10,835,827 | 297.7 kb | Distal (>10kb) Multiome HiCAR | 476 | |
| chr2:10,849,882–10,851,025 | 282.8 kb | Distal (>10kb) Multiome | 128 | |
| chr2:10,873,608–10,874,413 | 259.1 kb | Distal (>10kb) Multiome | 91 | |
| chr2:10,909,746–10,910,391 | 223.1 kb | Distal (>10kb) Multiome | 127 | |
| chr2:10,910,935–10,912,648 | 221.5 kb | Distal (>10kb) Multiome | 421 | |
| chr2:11,124,534–11,124,762 | 8.4 kb | Proximal (<10kb) | 242 | |
| chr2:11,129,508–11,130,490 | 3.1 kb | Proximal (<10kb) Multiome | 660 | |
| chr2:11,132,494–11,133,872 | 222 bp | At TSS Multiome | 774 | |
| chr2:11,135,015–11,135,588 | 1.9 kb | Proximal (<10kb) | 15 | |
| chr2:11,154,551–11,156,096 | 22.2 kb | Distal (>10kb) Multiome | 845 | |
| chr2:11,343,518–11,345,475 | 211.6 kb | Distal (>10kb) Multiome HiCAR | 1010 | |
| chr2:11,465,452–11,466,561 | 333.0 kb | Distal (>10kb) Multiome HiCAR | 1149 |
Genomic view of the C2orf50 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.