chr17:42,389,749–42,390,415

chr17 : 42,389,749 – 42,390,415

666 bp 95 TFs 13 linked genes

This 666 bp open chromatin element is linked to 13 target genes and is bound by 95 transcription factors.

Linked Genes

13 genes

Gene	Expression	Dist. to TSS	Distance	Link type
STAT3		1.3 kb	Proximal	Proximity
ATP6V0A1		68.7 kb	Distal	Multiome
STAT5B		113.8 kb	Distal	Multiome
NAGLU		146.1 kb	Distal	Multiome
COASY		172.0 kb	Distal	Multiome
MLX		176.9 kb	Distal	Multiome
PSMC3IP		187.5 kb	Distal	Multiome
GHDC		195.7 kb	Distal	Multiome
RETREG3		219.2 kb	Distal	Multiome
TUBG1		219.5 kb	Distal	Multiome
RAB5C		235.2 kb	Distal	Multiome
KAT2A		268.8 kb	Distal	Multiome
TUBG2		269.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

95 transcription factors

ARID1A 2 datasets

ChIP RMG-I GSE104545.ARID1A.RMG-I 266 bp overlap

ChIP RMG-I GSE104545.ARID1A.RMG-I 92 bp overlap

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 279 bp overlap

ChIP K562 ENCFF938UXQ 541 bp overlap

ARID2 1 dataset

ChIP Aska-SS_shSSX GSE108025.ARID2.Aska-SS_shSSX 151 bp overlap

ARID3A 1 dataset

ChIP HepG2 ENCFF341DES 447 bp overlap

ChIP K562 ENCFF980NSF 251 bp overlap

BHLHE40 2 datasets

ChIP A549 ENCFF980EQQ 251 bp overlap

ChIP K-562 ENCSR000EGV.BHLHE40.K-562 157 bp overlap

ChIP K-562_iBET-BD2-IFNG GSE138084.BRD3.K-562_iBET-BD2-IFNG 319 bp overlap

BRD4 4 datasets

ChIP CLL_patient1 GSE109411.BRD4.CLL_patient1 258 bp overlap

ChIP CLL_patient3 GSE109411.BRD4.CLL_patient3 207 bp overlap

ChIP CLL_patient4 GSE109411.BRD4.CLL_patient4 342 bp overlap

ChIP K-562_iBET-IFNG GSE138084.BRD4.K-562_iBET-IFNG 248 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 261 bp overlap

ChIP K562 ENCFF963TXY 381 bp overlap

CBFA2T3 3 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 363 bp overlap

ChIP K-562 GSE142227.CBFA2T3.K-562 160 bp overlap

ChIP K562 ENCFF673OEZ 283 bp overlap

CEBPD 1 dataset

ChIP K-562 ENCSR000BVY.CEBPD.K-562 156 bp overlap

CTBP1 1 dataset

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 229 bp overlap

ChIP pancreas ENCFF759HAE 89 bp overlap

CUX1 5 datasets

Motif DE_72h DE_72h-CUX1_MA0754.3 9 bp overlap

ChIP Hep-G2 ENCSR049KIZ.CUX1.Hep-G2 186 bp overlap

ChIP K-562 GSE92882.CUX1.K-562 179 bp overlap

ChIP K-562_shCUX1-A GSE92882.CUX1.K-562_shCUX1-A 160 bp overlap

ChIP K562 ENCFF057AIX 345 bp overlap

Motif DE_72h DE_72h-CUX2_MA0755.2 9 bp overlap

CXXC5 1 dataset

ChIP K562 ENCFF497CZN 561 bp overlap

ChIP K562 ENCFF775HUO 570 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 228 bp overlap

FOXA1 2 datasets

ChIP HepG2 ENCFF207NVJ 281 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 466 bp overlap

FOXA2 4 datasets

ChIP DE DE-FOXA2-1 666 bp overlap

ChIP DE DE-FOXA2-2 652 bp overlap

ChIP liver_CARN1618 ERP008682.FOXA2.liver_CARN1618 361 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 527 bp overlap

FOXC2 1 dataset

Motif DE_72h DE_72h-FOXC2_MA0846.2 11 bp overlap

FOXD2 1 dataset

Motif DE_72h DE_72h-FOXD2_MA0847.4 11 bp overlap

FOXF2 1 dataset

Motif DE_72h DE_72h-FOXF2_MA0030.2 9 bp overlap

FOXH1 1 dataset

Motif DE_72h DE_72h-FOXH1_MA0479.2 8 bp overlap

FOXK1 2 datasets

Motif DE_72h DE_72h-FOXK1_MA0852.3 7 bp overlap

ChIP Hep-G2 ENCSR603BJQ.FOXK1.Hep-G2 164 bp overlap

FOXK2 1 dataset

Motif DE_72h DE_72h-FOXK2_MA1103.3 7 bp overlap

FOXL1 1 dataset

Motif DE_72h DE_72h-FOXL1_MA0033.2 7 bp overlap

FOXO4 1 dataset

Motif DE_72h DE_72h-FOXO4_MA0848.1 7 bp overlap

FOXO6 1 dataset

Motif DE_72h DE_72h-FOXO6_MA0849.1 7 bp overlap

FOXP1 2 datasets

ChIP Hep-G2 ENCSR369YUK.FOXP1.Hep-G2 215 bp overlap

ChIP HepG2 ENCFF823ERM 341 bp overlap

FOXP2 1 dataset

Motif DE_72h DE_72h-FOXP2_MA0593.2 9 bp overlap

FOXP3 1 dataset

Motif DE_72h DE_72h-FOXP3_MA0850.1 7 bp overlap

Foxf1 1 dataset

Motif DE_72h DE_72h-Foxf1_MA1606.2 7 bp overlap

Foxl2 1 dataset

Motif DE_72h DE_72h-Foxl2_MA1607.2 10 bp overlap

Foxo1 1 dataset

Motif DE_72h DE_72h-Foxo1_MA0480.3 7 bp overlap

Foxo3 1 dataset

Motif DE_72h DE_72h-Foxo3_MA0157.4 7 bp overlap

GATA1 5 datasets

ChIP K-562 GSE107726.GATA1.K-562 274 bp overlap

ChIP K-562 ENCSR000EFT.GATA1.K-562 129 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 247 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 215 bp overlap

ChIP K562 ENCFF094CMK 251 bp overlap

GATA2 1 dataset

ChIP K-562 ENCSR000BKM.GATA2.K-562 129 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 587 bp overlap

ChIP DE DE-GATA4-2 636 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 300 bp overlap

ChIP foregut GSE117136.GATA4.foregut 566 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 666 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 581 bp overlap

GATA6 13 datasets

ChIP AGS GSE51705.GATA6.AGS 146 bp overlap

ChIP DE DE-GATA6-1 593 bp overlap

ChIP DE DE-GATA6-2 631 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 541 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 256 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 458 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 352 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 522 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 411 bp overlap

ChIP foregut GSE117136.GATA6.foregut 584 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 666 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 535 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 625 bp overlap

GATAD2A 1 dataset

ChIP HepG2 ENCFF252XNH 465 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 200 bp overlap

HDAC1 6 datasets

ChIP HepG2 ENCFF750ZWM 666 bp overlap

ChIP K-562 ENCSR387UWP.HDAC1.K-562 301 bp overlap

ChIP K-562 ENCSR711VWL.HDAC1.K-562 281 bp overlap

ChIP K562 ENCFF928TKZ 457 bp overlap

ChIP K562 ENCFF968WBH 521 bp overlap

ChIP K562 ENCFF968WBH 411 bp overlap

HDAC2 3 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 410 bp overlap

ChIP K-562 ENCSR000BMG.HDAC2.K-562 116 bp overlap

ChIP K562 ENCFF744ALD 126 bp overlap

KDM1A 6 datasets

ChIP K-562 ENCSR908CMW.KDM1A.K-562 334 bp overlap

ChIP K-562 ENCSR360HRA.KDM1A.K-562 249 bp overlap

ChIP K562 ENCFF128TYE 461 bp overlap

ChIP K562 ENCFF133OLU 461 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 330 bp overlap

ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 253 bp overlap

KLF16 1 dataset

ChIP K562 ENCFF464PIV 345 bp overlap

ChIP Hep-G2 ENCSR757EKM.KLF6.Hep-G2 378 bp overlap

Motif DE_72h DE_72h-KLF9_MA1107.3 11 bp overlap

ChIP K-562 GSE142227.LDB1.K-562 336 bp overlap

ChIP CD4_Th1 GSE72266.MAF.CD4_Th1 166 bp overlap

MAFF 2 datasets

ChIP HepG2 ENCFF452YUT 277 bp overlap

ChIP K562 ENCFF071YKK 281 bp overlap

MAFK 3 datasets

ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 161 bp overlap

ChIP HepG2 ENCFF743ZOF 241 bp overlap

ChIP HepG2 ENCFF767LDG 257 bp overlap

MED1 2 datasets

ChIP G296S_4 GSE85628.MED1.G296S_4 244 bp overlap

ChIP G296S_4 GSE85628.MED1.G296S_4 153 bp overlap

MEIS2 2 datasets

ChIP K-562 ENCSR851BNE.MEIS2.K-562 278 bp overlap

ChIP K562 ENCFF320GSD 381 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 266 bp overlap

ChIP CC-LP-1 GSE124430.MYC.CC-LP-1 479 bp overlap

ChIP K-562 ENCSR000EZU.MYC.K-562 128 bp overlap

ChIP COG-N-415 GSE138295.MYCN.COG-N-415 312 bp overlap

NCAPH2 2 datasets

ChIP RMG-I GSE120058.NCAPH2.RMG-I 666 bp overlap

ChIP RMG-I_ARID1A-KO GSE120058.NCAPH2.RMG-I_ARID1A-KO 650 bp overlap

NCOR1 1 dataset

ChIP K-562 ENCSR798ILC.NCOR1.K-562 235 bp overlap

NFATC3 1 dataset

ChIP GM12878 ENCSR437GBJ.NFATC3.GM12878 98 bp overlap

NFKBIZ 1 dataset

ChIP Hep-G2 ENCSR235OVI.NFKBIZ.Hep-G2 378 bp overlap

ONECUT1 6 datasets

Motif DE_72h DE_72h-ONECUT1_MA0679.3 9 bp overlap

ChIP H9 ERP004206.ONECUT1.H9 462 bp overlap

ChIP Hep-G2 ENCSR956OSX.ONECUT1.Hep-G2 104 bp overlap

ChIP Hep-G2 ENCSR956OSX.ONECUT1.Hep-G2 272 bp overlap

ChIP HepG2 ENCFF243FIR 341 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 612 bp overlap

ONECUT2 1 dataset

Motif DE_72h DE_72h-ONECUT2_MA0756.3 8 bp overlap

ONECUT3 1 dataset

Motif DE_72h DE_72h-ONECUT3_MA0757.2 12 bp overlap

OVOL2 1 dataset

ChIP WTC11 ENCFF780XKS 391 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 436 bp overlap

ChIP HEK293_ab833 GSE101646.PHIP.HEK293_ab833 255 bp overlap

POU5F1 1 dataset

ChIP BJ_INDUCED GSE36570.POU5F1.BJ_INDUCED 136 bp overlap

PRDM10 2 datasets

ChIP HEK293 ENCFF145WQQ 238 bp overlap

ChIP K562 ENCFF740YLK 417 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 271 bp overlap

ChIP HepG2 ENCFF989AQH 125 bp overlap

RCOR1 1 dataset

ChIP K562 ENCFF216EEJ 297 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 585 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 203 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 245 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 363 bp overlap

ChIP K-562 ENCSR788RSW.SOX6.K-562 288 bp overlap

STAT3 1 dataset

ChIP MCF-10A ENCSR000DOQ.STAT3.MCF-10A 154 bp overlap

SUPT5H 1 dataset

ChIP HeLa_DOX GSE125534.SUPT5H.HeLa_DOX 477 bp overlap

TAL1 8 datasets

ChIP K-562 GSE107726.TAL1.K-562 304 bp overlap

ChIP K-562 ENCSR000EHB.TAL1.K-562 161 bp overlap

ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 151 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 269 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 250 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 231 bp overlap

ChIP K562 ENCFF620GMX 385 bp overlap

ChIP ProEs GSE59087.TAL1.ProEs 128 bp overlap

TBX5 6 datasets

ChIP G296S GSE85628.TBX5.G296S 666 bp overlap

ChIP G296S_2 GSE85628.TBX5.G296S_2 666 bp overlap

ChIP G296S_4 GSE85628.TBX5.G296S_4 207 bp overlap

ChIP G296S_4 GSE85628.TBX5.G296S_4 297 bp overlap

ChIP cardiomyocyte GSE85628.TBX5.cardiomyocyte 398 bp overlap

ChIP cardiomyocyte_1 GSE85628.TBX5.cardiomyocyte_1 398 bp overlap

TCF12 1 dataset

ChIP K-562 ENCSR744WOO.TCF12.K-562 200 bp overlap

ChIP K-562 ENCSR970OJY.TCF3.K-562 206 bp overlap

TEAD4 1 dataset

ChIP K562 ENCFF673NIK 365 bp overlap

ZBTB20 1 dataset

ChIP HEK293 ENCSR460MBI.ZBTB20.HEK293 150 bp overlap

ZBTB33 1 dataset

ChIP HepG2 ENCFF778UKV 337 bp overlap

ZBTB7A 1 dataset

ChIP K-562 GSE103445.ZBTB7A.K-562 139 bp overlap

ChIP K-562 ENCSR004GKA.ZEB2.K-562 299 bp overlap

ZNF143 1 dataset

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 145 bp overlap

ZNF157 1 dataset

Motif DE_72h DE_72h-ZNF157_MA2331.1 21 bp overlap

ZNF276 1 dataset

ChIP Hep-G2 ENCSR076KLJ.ZNF276.Hep-G2 205 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 180 bp overlap

ZNF341 1 dataset

Motif DE_72h DE_72h-ZNF341_MA1655.2 8 bp overlap

ZNF592 1 dataset

ChIP GM12878 ENCFF818ABS 51 bp overlap

ZSCAN4 1 dataset

Motif DE_72h DE_72h-ZSCAN4_MA1155.1 15 bp overlap