MLX

MAX dimerization protein MLX | MAD7, MXD7, bHLHd13, TCFL4

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 34 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)glucose homeostasis (GO:0042593)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating MLX 0 TFs

Transcription factors with Perturb-seq knockdown data for MLX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MLX

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:42,275,506–42,277,052	290.7 kb	Distal (>10kb) Multiome	892
chr17:42,288,257–42,288,808	278.6 kb	Distal (>10kb) Multiome	449
chr17:42,312,237–42,312,887	254.6 kb	Distal (>10kb) Multiome	774
chr17:42,387,693–42,389,289	178.5 kb	Distal (>10kb) Multiome	1178
chr17:42,389,749–42,390,415	176.9 kb	Distal (>10kb) Multiome	95
chr17:42,422,618–42,423,513	143.9 kb	Distal (>10kb) Multiome	765
chr17:42,531,503–42,532,256	35.2 kb	Distal (>10kb) Multiome	571
chr17:42,535,863–42,536,855	30.8 kb	Distal (>10kb) Multiome	987
chr17:42,547,934–42,548,909	18.7 kb	Distal (>10kb) Multiome	325
chr17:42,554,285–42,555,164	12.3 kb	Distal (>10kb) Multiome	899
chr17:42,561,770–42,562,376	5.0 kb	Proximal (<10kb) Multiome	905
chr17:42,566,552–42,567,732	31 bp	At TSS Multiome	902
chr17:42,577,421–42,578,281	10.7 kb	Distal (>10kb) Multiome	884
chr17:42,578,382–42,578,892	11.6 kb	Distal (>10kb) Multiome	477
chr17:42,608,764–42,610,335	42.4 kb	Distal (>10kb) Multiome	909
chr17:42,658,938–42,659,852	92.2 kb	Distal (>10kb) Multiome	734
chr17:42,669,472–42,671,112	103.6 kb	Distal (>10kb) Multiome	230
chr17:42,673,584–42,674,462	106.9 kb	Distal (>10kb) Multiome	296
chr17:42,674,847–42,675,579	108.1 kb	Distal (>10kb) Multiome	194
chr17:42,676,055–42,678,790	110.0 kb	Distal (>10kb) Multiome	1070
chr17:42,679,005–42,680,519	112.8 kb	Distal (>10kb) Multiome	654
chr17:42,682,736–42,683,400	115.7 kb	Distal (>10kb) Multiome	480
chr17:42,744,352–42,745,375	177.9 kb	Distal (>10kb) Multiome	966
chr17:42,761,003–42,761,468	193.9 kb	Distal (>10kb) Multiome	335
chr17:42,780,029–42,780,899	213.4 kb	Distal (>10kb) Multiome	712
chr17:42,798,408–42,798,877	231.6 kb	Distal (>10kb) Multiome	866
chr17:42,823,968–42,824,503	257.2 kb	Distal (>10kb) Multiome	829
chr17:42,832,889–42,833,841	266.3 kb	Distal (>10kb) Multiome	980

Genome Browser

Genomic view of the MLX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.