KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Transcription factors with Perturb-seq knockdown data for KAT2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KAT2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KAT2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,121,452–40,123,602 | 1999.5 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr17:41,835,756–41,836,400 | 285.2 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 255.9 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 207.3 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 202.2 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 190.8 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 154.6 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 103.9 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 101.3 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 70.8 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 13.5 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,116,786–42,117,012 | 4.4 kb | Proximal (<10kb) | 316 | |
| chr17:42,120,858–42,121,715 | 123 bp | At TSS Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 1.3 kb | Proximal (<10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 33.8 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,180,242–42,180,762 | 59.0 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 62.9 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,275,506–42,277,052 | 155.0 kb | Distal (>10kb) Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 167.2 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 191.1 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 267.3 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 268.8 kb | Distal (>10kb) Multiome | 95 |
Genomic view of the KAT2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.