OVOL2
ovo like zinc finger 2 | CHED, HOVO2, bA504H3.3, CHED1, ZNF339

This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

Member of: DE-3 DE-3.38
Biological processes 46 terms
DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin binding (GO:0003682)epidermal cell differentiation (GO:0009913)epidermal cell differentiation (GO:0009913)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of cell differentiation (GO:0045596)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of gene expression (GO:0010629)negative regulation of gene expression (GO:0010629)negative regulation of keratinocyte differentiation (GO:0045617)negative regulation of multicellular organismal process (GO:0051241)negative regulation of signal transduction (GO:0009968)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of white fat cell proliferation (GO:0070351)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of brown fat cell differentiation (GO:0090336)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of cell cycle (GO:0051726)regulation of keratinocyte differentiation (GO:0045616)regulation of keratinocyte proliferation (GO:0010837)regulation of keratinocyte proliferation (GO:0010837)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription corepressor activity (GO:0003714)
Expression (TPM)
OVOL2 — as a Regulated Gene

TFs regulating OVOL2 0 TFs

Transcription factors with Perturb-seq knockdown data for OVOL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OVOL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to OVOL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OVOL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr20:17,938,730–17,940,231 120.0 kb Distal (>10kb) Multiome 678
chr20:17,968,085–17,969,639 90.3 kb Distal (>10kb) Multiome 1144
chr20:18,032,971–18,033,755 26.0 kb Distal (>10kb) Multiome 212
chr20:18,056,208–18,057,025 890 bp At TSS 262
chr20:18,057,257–18,058,052 1.3 kb Proximal (<10kb) Multiome 323
chr20:18,058,764–18,059,467 10 bp At TSS Multiome 393
chr20:18,101,249–18,101,961 42.5 kb Distal (>10kb) Multiome 74
chr20:18,103,190–18,103,994 44.5 kb Distal (>10kb) Multiome 149
chr20:18,137,127–18,138,367 78.7 kb Distal (>10kb) Multiome 1046
chr20:18,287,674–18,288,982 229.1 kb Distal (>10kb) Multiome HiCAR 971

Genome Browser

Genomic view of the OVOL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr20:17,928,730 – 18,298,982
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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