RETREG3

reticulophagy regulator family member 3 | DKFZp686B1036, FLJ33806, FAM134C

Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Involved in endoplasmic reticulum tubular network organization; positive regulation of neuron projection development; and reticulophagy. Located in endoplasmic reticulum tubular network. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.4

Biological processes 11 terms

endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum tubular network (GO:0071782)endoplasmic reticulum tubular network organization (GO:0071786)endoplasmic reticulum-autophagosome adaptor activity (GO:0140506)positive regulation of neuron projection development (GO:0010976)protein binding (GO:0005515)protein-containing complex (GO:0032991)reticulophagy (GO:0061709)reticulophagy (GO:0061709)substrate localization to autophagosome (GO:0061753)

Expression (TPM)

TFs regulating RETREG3 0 TFs

Transcription factors with Perturb-seq knockdown data for RETREG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RETREG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RETREG3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RETREG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:42,312,237–42,312,887	296.9 kb	Distal (>10kb) Multiome	774
chr17:42,387,693–42,389,289	220.7 kb	Distal (>10kb) Multiome	1178
chr17:42,389,749–42,390,415	219.2 kb	Distal (>10kb) Multiome	95
chr17:42,422,618–42,423,513	186.2 kb	Distal (>10kb) Multiome	765
chr17:42,531,503–42,532,256	77.4 kb	Distal (>10kb) Multiome	571
chr17:42,535,863–42,536,855	73.1 kb	Distal (>10kb) Multiome	987
chr17:42,547,934–42,548,909	60.9 kb	Distal (>10kb) Multiome	325
chr17:42,554,285–42,555,164	54.6 kb	Distal (>10kb) Multiome	899
chr17:42,561,770–42,562,376	47.3 kb	Distal (>10kb) Multiome	905
chr17:42,566,552–42,567,732	42.3 kb	Distal (>10kb) Multiome	902
chr17:42,577,421–42,578,281	31.6 kb	Distal (>10kb) Multiome	884
chr17:42,578,382–42,578,892	30.7 kb	Distal (>10kb) Multiome	477
chr17:42,608,764–42,610,335	137 bp	At TSS Multiome	909
chr17:42,658,938–42,659,852	49.9 kb	Distal (>10kb) Multiome	734
chr17:42,669,472–42,671,112	61.4 kb	Distal (>10kb) Multiome	230
chr17:42,673,584–42,674,462	64.6 kb	Distal (>10kb) Multiome	296
chr17:42,674,847–42,675,579	65.8 kb	Distal (>10kb) Multiome	194
chr17:42,676,055–42,678,790	67.8 kb	Distal (>10kb) Multiome	1070
chr17:42,679,005–42,680,519	70.5 kb	Distal (>10kb) Multiome	654
chr17:42,682,736–42,683,400	73.4 kb	Distal (>10kb) Multiome	480
chr17:42,744,352–42,745,375	135.6 kb	Distal (>10kb) Multiome	966
chr17:42,761,003–42,761,468	151.7 kb	Distal (>10kb) Multiome	335
chr17:42,780,029–42,780,899	171.2 kb	Distal (>10kb) Multiome	712
chr17:42,798,408–42,798,877	189.3 kb	Distal (>10kb) Multiome	866
chr17:42,823,968–42,824,503	214.9 kb	Distal (>10kb) Multiome	829
chr17:42,832,889–42,833,841	224.0 kb	Distal (>10kb) Multiome	980

Genome Browser

Genomic view of the RETREG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.