TUBG2

tubulin gamma 2

Predicted to enable GTP binding activity and microtubule nucleator activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Located in microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6

Biological processes 28 terms

GTP binding (GO:0005525)GTP binding (GO:0005525)centriolar satellite (GO:0034451)centrosome (GO:0005813)centrosome (GO:0005813)cytoplasm (GO:0005737)cytoplasmic microtubule (GO:0005881)cytoplasmic microtubule organization (GO:0031122)cytosol (GO:0005829)gamma-tubulin complex (GO:0000930)gamma-tubulin ring complex (GO:0000931)meiotic spindle organization (GO:0000212)microtubule (GO:0005874)microtubule (GO:0005874)microtubule cytoskeleton (GO:0015630)microtubule cytoskeleton (GO:0015630)microtubule nucleation (GO:0007020)microtubule nucleation (GO:0007020)microtubule nucleator activity (GO:0140490)microtubule-based process (GO:0007017)mitotic cell cycle (GO:0000278)mitotic sister chromatid segregation (GO:0000070)mitotic spindle organization (GO:0007052)nucleus (GO:0005634)pericentriolar material (GO:0000242)spindle (GO:0005819)spindle microtubule (GO:0005876)structural molecule activity (GO:0005198)

Expression (TPM)

TFs regulating TUBG2 0 TFs

Transcription factors with Perturb-seq knockdown data for TUBG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TUBG2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:42,387,693–42,389,289	270.6 kb	Distal (>10kb) Multiome	1178
chr17:42,389,749–42,390,415	269.1 kb	Distal (>10kb) Multiome	95
chr17:42,422,618–42,423,513	236.1 kb	Distal (>10kb) Multiome	765
chr17:42,531,503–42,532,256	127.3 kb	Distal (>10kb) Multiome	571
chr17:42,535,863–42,536,855	123.0 kb	Distal (>10kb) Multiome	987
chr17:42,547,934–42,548,909	110.8 kb	Distal (>10kb) Multiome	325
chr17:42,554,285–42,555,164	104.5 kb	Distal (>10kb) Multiome	899
chr17:42,561,770–42,562,376	97.2 kb	Distal (>10kb) Multiome	905
chr17:42,566,552–42,567,732	92.2 kb	Distal (>10kb) Multiome	902
chr17:42,577,421–42,578,281	81.5 kb	Distal (>10kb) Multiome	884
chr17:42,578,382–42,578,892	80.6 kb	Distal (>10kb) Multiome	477
chr17:42,608,764–42,610,335	49.8 kb	Distal (>10kb) Multiome	909
chr17:42,658,938–42,659,852	25 bp	At TSS Multiome	734
chr17:42,669,472–42,671,112	11.5 kb	Distal (>10kb) Multiome	230
chr17:42,673,584–42,674,462	14.7 kb	Distal (>10kb) Multiome	296
chr17:42,674,847–42,675,579	15.9 kb	Distal (>10kb) Multiome	194
chr17:42,676,055–42,678,790	17.8 kb	Distal (>10kb) Multiome	1070
chr17:42,679,005–42,680,519	20.6 kb	Distal (>10kb) Multiome	654
chr17:42,682,736–42,683,400	23.5 kb	Distal (>10kb) Multiome	480
chr17:42,744,352–42,745,375	85.7 kb	Distal (>10kb) Multiome	966
chr17:42,761,003–42,761,468	101.8 kb	Distal (>10kb) Multiome	335
chr17:42,780,029–42,780,899	121.2 kb	Distal (>10kb) Multiome	712
chr17:42,798,408–42,798,877	139.4 kb	Distal (>10kb) Multiome	866
chr17:42,823,968–42,824,503	165.0 kb	Distal (>10kb) Multiome	829
chr17:42,832,889–42,833,841	174.1 kb	Distal (>10kb) Multiome	980

Genome Browser

Genomic view of the TUBG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.