This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for TUBG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,312,237–42,312,887 | 297.2 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 221.0 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 219.5 kb | Distal (>10kb) Multiome | 95 | |
| chr17:42,422,618–42,423,513 | 186.5 kb | Distal (>10kb) Multiome | 765 | |
| chr17:42,531,503–42,532,256 | 77.7 kb | Distal (>10kb) Multiome | 571 | |
| chr17:42,535,863–42,536,855 | 73.4 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 61.2 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 54.9 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 47.6 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 42.6 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 31.9 kb | Distal (>10kb) Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 31.0 kb | Distal (>10kb) Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 171 bp | At TSS Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 49.6 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 61.1 kb | Distal (>10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 64.3 kb | Distal (>10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 65.5 kb | Distal (>10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 67.4 kb | Distal (>10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 70.2 kb | Distal (>10kb) Multiome | 654 | |
| chr17:42,682,736–42,683,400 | 73.1 kb | Distal (>10kb) Multiome | 480 | |
| chr17:42,744,352–42,745,375 | 135.3 kb | Distal (>10kb) Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 151.4 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 170.8 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 189.0 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 214.6 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 223.7 kb | Distal (>10kb) Multiome | 980 |
Genomic view of the TUBG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.