This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for PSMC3IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMC3IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMC3IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,288,257–42,288,808 | 289.2 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 265.2 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 189.1 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 187.5 kb | Distal (>10kb) Multiome | 95 | |
| chr17:42,422,618–42,423,513 | 154.5 kb | Distal (>10kb) Multiome | 765 | |
| chr17:42,531,503–42,532,256 | 45.8 kb | Distal (>10kb) Multiome | 571 | |
| chr17:42,535,863–42,536,855 | 41.4 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 29.2 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 22.9 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 15.6 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 10.6 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 90 bp | At TSS Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 995 bp | At TSS Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 31.8 kb | Distal (>10kb) Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 81.6 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 93.0 kb | Distal (>10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 96.3 kb | Distal (>10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 97.5 kb | Distal (>10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 99.4 kb | Distal (>10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 102.2 kb | Distal (>10kb) Multiome | 654 | |
| chr17:42,682,736–42,683,400 | 105.1 kb | Distal (>10kb) Multiome | 480 | |
| chr17:42,744,352–42,745,375 | 167.3 kb | Distal (>10kb) Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 183.3 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 202.8 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 221.0 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 246.6 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 255.7 kb | Distal (>10kb) Multiome | 980 |
Genomic view of the PSMC3IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.