This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP6V0A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V0A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V0A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,180,242–42,180,762 | 278.5 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 274.6 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,275,506–42,277,052 | 182.5 kb | Distal (>10kb) Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 170.3 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 146.4 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 70.2 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 68.7 kb | Distal (>10kb) Multiome | 95 | |
| chr17:42,422,618–42,423,513 | 35.7 kb | Distal (>10kb) Multiome | 765 | |
| chr17:42,458,641–42,458,983 | at TSS | At TSS | 738 | |
| chr17:42,531,503–42,532,256 | 73.1 kb | Distal (>10kb) Multiome | 571 | |
| chr17:42,535,863–42,536,855 | 77.5 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 89.6 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 95.9 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 103.2 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 108.2 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 118.9 kb | Distal (>10kb) Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 119.8 kb | Distal (>10kb) Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 150.6 kb | Distal (>10kb) Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 200.4 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 211.9 kb | Distal (>10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 215.1 kb | Distal (>10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 216.4 kb | Distal (>10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 218.3 kb | Distal (>10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 221.0 kb | Distal (>10kb) Multiome | 654 | |
| chr17:42,682,736–42,683,400 | 223.9 kb | Distal (>10kb) Multiome | 480 | |
| chr17:42,744,352–42,745,375 | 286.1 kb | Distal (>10kb) Multiome | 966 |
Genomic view of the ATP6V0A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.