Predicted to enable acid-amino acid ligase activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GHDC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GHDC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GHDC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,913,670–41,914,569 | 280.4 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 275.3 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 263.9 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 227.7 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 177.0 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 174.4 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 143.8 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 86.6 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,120,858–42,121,715 | 73.2 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 71.8 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 39.3 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,183,755–42,184,761 | 10.2 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,194,413–42,194,644 | at TSS | At TSS | 628 | |
| chr17:42,275,506–42,277,052 | 81.9 kb | Distal (>10kb) Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 94.1 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 118.0 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 194.2 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 195.7 kb | Distal (>10kb) Multiome | 95 | |
| chr17:42,422,618–42,423,513 | 228.7 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the GHDC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.