chr15:45,376,152–45,377,230

chr15 : 45,376,152 – 45,377,230

1,078 bp 97 TFs 7 linked genes

This 1.1 kb open chromatin element is linked to 7 target genes and is bound by 97 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
GATM		at TSS	At TSS	Proximity
ENSG00000275672		1.5 kb	Proximal	Proximity
SLC30A4		146.2 kb	Distal	Multiome
SHF		175.4 kb	Distal	Multiome
ENSG00000259539		209.0 kb	Distal	Multiome
BLOC1S6		210.8 kb	Distal	Multiome
DUOX1		246.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

97 transcription factors

ARID3A 1 dataset

ChIP HepG2 ENCFF341DES 525 bp overlap

ASCL1 3 datasets

Motif DE_48h DE_48h-ASCL1_MA1631.2 9 bp overlap

Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap

Motif DE_72h DE_72h-ASCL1_MA1631.2 9 bp overlap

ChIP OCI-Ly1 GSE29282.BCL6.OCI-Ly1 239 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 174 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 201 bp overlap

BRD4 2 datasets

ChIP CLL_patient1_4h_CpG GSE109411.BRD4.CLL_patient1_4h_CpG 242 bp overlap

ChIP CLL_patient4 GSE109411.BRD4.CLL_patient4 228 bp overlap

ChIP KB_IL GSE52469.CDK6.KB_IL 189 bp overlap

CREBBP 1 dataset

ChIP tonsil_GCBc_p4 GSE89688.CREBBP.tonsil_GCBc_p4 211 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF896HSY 70 bp overlap

DUX4 4 datasets

Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap

Motif DE_72h DE_72h-DUX4_MA0468.1 11 bp overlap

ChIP HEK293 GSE75791.DUX4.HEK293 342 bp overlap

ChIP WA01 GSE94322.DUX4.WA01 471 bp overlap

DUXA 2 datasets

Motif DE_60h DE_60h-DUXA_MA0884.2 13 bp overlap

Motif DE_72h DE_72h-DUXA_MA0884.2 13 bp overlap

ChIP ProEs GSE59087.EED.ProEs 188 bp overlap

ChIP Hep-G2 ENCSR026GSW.EGR1.Hep-G2 145 bp overlap

EOMES 4 datasets

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

Motif DE_72h DE_72h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 195 bp overlap

ChIP hESC GSE26097.EOMES.hESC 154 bp overlap

ChIP SKNO-1 GSE23730.ERG.SKNO-1 217 bp overlap

ChIP MDA-MB-134-VI_ESTROGEN GSE51022.ESR1.MDA-MB-134-VI_ESTROGEN 276 bp overlap

ChIP RWPE-1_FLAG GSE29808.ETV1.RWPE-1_FLAG 296 bp overlap

ETV5::FIGLA 3 datasets

Motif DE_48h DE_48h-ETV5FIGLA_MA1945.2 14 bp overlap

Motif DE_60h DE_60h-ETV5FIGLA_MA1945.2 14 bp overlap

Motif DE_72h DE_72h-ETV5FIGLA_MA1945.2 14 bp overlap

EZH2 16 datasets

ChIP A-673 ENCSR179SAO.EZH2.A-673 222 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 427 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 144 bp overlap

ChIP GM23248 ENCFF404ZHM 426 bp overlap

ChIP GM23248 ENCSR131FFJ.EZH2.GM23248 225 bp overlap

ChIP OCI-LY7 ENCFF395KPU 112 bp overlap

ChIP OCI-LY7 ENCFF434OYG 112 bp overlap

ChIP RH30_DMSO GSE85169.EZH2.RH30_DMSO 289 bp overlap

ChIP SU-DHL-5 GSE45982.EZH2.SU-DHL-5 73 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 62 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 236 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 236 bp overlap

ChIP fibroblast_LUNG ENCSR000ARO.EZH2.fibroblast_LUNG 379 bp overlap

ChIP hepatocyte ENCSR384LYW.EZH2.hepatocyte 445 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 208 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 198 bp overlap

Motif DE_48h DE_48h-Elf5_MA0136.4 8 bp overlap

FIGLA 3 datasets

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

FLI1 3 datasets

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 233 bp overlap

ChIP A-673_D17 GSE129155.FLI1.A-673_D17 225 bp overlap

ChIP SKNO-1 GSE23730.FLI1.SKNO-1 269 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 1045 bp overlap

ChIP DE DE-FOXA2-2 404 bp overlap

ChIP DE DE-FOXA2-2 451 bp overlap

FOXP1 1 dataset

ChIP LNCaP GSE62492.FOXP1.LNCaP 232 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 972 bp overlap

ChIP DE DE-GATA4-2 1051 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 1074 bp overlap

ChIP DE DE-GATA6-2 1062 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 1008 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 999 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 996 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 978 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 1028 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 1008 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 547 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 361 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 342 bp overlap

HIF1A 1 dataset

ChIP U2OS_trough_DMOG GSE85096.HIF1A.U2OS_trough_DMOG 226 bp overlap

Hand1 2 datasets

Motif DE_60h DE_60h-Hand1_MA2123.1 9 bp overlap

Motif DE_72h DE_72h-Hand1_MA2123.1 9 bp overlap

IKZF2 1 dataset

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

MEIS1 3 datasets

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MITF 4 datasets

ChIP 501-mel GSE137522.MITF.501-mel 96 bp overlap

ChIP 501-mel_20ng_K243R GSE137522.MITF.501-mel_20ng_K243R 122 bp overlap

ChIP 501-mel_K243Q GSE137522.MITF.501-mel_K243Q 81 bp overlap

ChIP K-562 ENCSR797SWM.MITF.K-562 84 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 565 bp overlap

ChIP RH4 GSE155861.MTA2.RH4 147 bp overlap

Motif DE_48h DE_48h-MXI1_MA1108.3 6 bp overlap

MYBL2 1 dataset

ChIP A-673 GSE119971.MYBL2.A-673 196 bp overlap

ChIP CD34 GSE85488.MYC.CD34 113 bp overlap

MYOD1 3 datasets

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 681 bp overlap

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 221 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 116 bp overlap

MYOG 2 datasets

ChIP RH30_DMSO GSE85169.MYOG.RH30_DMSO 337 bp overlap

ChIP RH4_DMSO-6H GSE116344.MYOG.RH4_DMSO-6H 114 bp overlap

NELFE 1 dataset

ChIP K-562_NHS GSE112379.NELFE.K-562_NHS 191 bp overlap

NEUROD1 2 datasets

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 104 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 277 bp overlap

NEUROG2 6 datasets

ChIP MRC-5_NFD_02DPT GSE75910.NEUROG2.MRC-5_NFD_02DPT 157 bp overlap

ChIP MRC-5_NFD_05DPT GSE75910.NEUROG2.MRC-5_NFD_05DPT 183 bp overlap

ChIP MRC-5_NFD_1DPT GSE75910.NEUROG2.MRC-5_NFD_1DPT 192 bp overlap

ChIP MRC-5_N_02DPT GSE75910.NEUROG2.MRC-5_N_02DPT 208 bp overlap

ChIP MRC-5_N_05DPT GSE75910.NEUROG2.MRC-5_N_05DPT 155 bp overlap

ChIP MRC-5_N_1DPT GSE75910.NEUROG2.MRC-5_N_1DPT 209 bp overlap

ChIP hiPSC GSE125768.PDX1.hiPSC 238 bp overlap

PHOX2A 2 datasets

Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap

Motif DE_72h DE_72h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 2 datasets

Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_72h DE_72h-PHOX2B_MA0681.3 12 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 55 bp overlap

POLR2A 2 datasets

ChIP body of pancreas ENCFF501FEC 637 bp overlap

ChIP body of pancreas ENCFF675RCN 625 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 267 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 245 bp overlap

PROP1 2 datasets

Motif DE_60h DE_60h-PROP1_MA0715.1 11 bp overlap

Motif DE_72h DE_72h-PROP1_MA0715.1 11 bp overlap

RAD51 3 datasets

ChIP K-562 ENCSR524BUE.RAD51.K-562 80 bp overlap

ChIP K562 ENCFF133ELP 99 bp overlap

ChIP MCF-7 ENCFF128SEB 99 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 200 bp overlap

RNF2 2 datasets

ChIP WA01 ENCSR784VUY.RNF2.WA01 310 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 451 bp overlap

Motif DE_48h DE_48h-Rarg_MA0860.1 17 bp overlap

Runx1 2 datasets

Motif DE_60h DE_60h-Runx1_MA0002.3 9 bp overlap

Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap

SCRT1 3 datasets

Motif DE_48h DE_48h-SCRT1_MA0743.3 10 bp overlap

Motif DE_60h DE_60h-SCRT1_MA0743.3 10 bp overlap

Motif DE_72h DE_72h-SCRT1_MA0743.3 10 bp overlap

SCRT2 3 datasets

Motif DE_48h DE_48h-SCRT2_MA0744.3 10 bp overlap

Motif DE_60h DE_60h-SCRT2_MA0744.3 10 bp overlap

Motif DE_72h DE_72h-SCRT2_MA0744.3 10 bp overlap

SMAD2 2 datasets

Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap

Motif DE_72h DE_72h-SMAD2_MA1964.2 6 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 973 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 534 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 359 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 330 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 307 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 261 bp overlap

SMARCA4 1 dataset

ChIP TTC-1240_delC GSE124903.SMARCA4.TTC-1240_delC 187 bp overlap

SNAI1 3 datasets

Motif DE_48h DE_48h-SNAI1_MA1558.2 7 bp overlap

Motif DE_60h DE_60h-SNAI1_MA1558.2 7 bp overlap

Motif DE_72h DE_72h-SNAI1_MA1558.2 7 bp overlap

SNAI2 1 dataset

ChIP SMS-CTR_D48 GSE137168.SNAI2.SMS-CTR_D48 245 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 348 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 726 bp overlap

SPI1 7 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 362 bp overlap

ChIP GM12891 ENCFF563IUT 241 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 151 bp overlap

ChIP HL-60 ENCFF645GBT 271 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 289 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 108 bp overlap

ChIP primary-B-cell_donorA GSE128834.SPI1.primary-B-cell_donorA 349 bp overlap

SREBF1 1 dataset

ChIP MCF-7 ENCSR197DJH.SREBF1.MCF-7 69 bp overlap

SUZ12 3 datasets

ChIP Aska-SS GSE108025.SUZ12.Aska-SS 552 bp overlap

ChIP CRL-7250_shSS18-SSX GSE108025.SUZ12.CRL-7250_shSS18-SSX 435 bp overlap

ChIP hiPSC_WT GSE124903.SUZ12.hiPSC_WT 208 bp overlap

Spz1 3 datasets

Motif DE_48h DE_48h-Spz1_MA0111.1 11 bp overlap

Motif DE_60h DE_60h-Spz1_MA0111.1 11 bp overlap

Motif DE_72h DE_72h-Spz1_MA0111.1 11 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 209 bp overlap

TBR1 2 datasets

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

Motif DE_72h DE_72h-TBR1_MA0802.2 9 bp overlap

TBX1 2 datasets

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

Motif DE_72h DE_72h-TBX1_MA0805.1 8 bp overlap

TBX15 2 datasets

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

Motif DE_72h DE_72h-TBX15_MA0803.1 8 bp overlap

TBX18 2 datasets

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

Motif DE_72h DE_72h-TBX18_MA1565.2 9 bp overlap

TBX19 2 datasets

Motif DE_60h DE_60h-TBX19_MA0804.2 17 bp overlap

Motif DE_72h DE_72h-TBX19_MA0804.2 17 bp overlap

TBX2 2 datasets

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

Motif DE_72h DE_72h-TBX2_MA0688.2 9 bp overlap

TBX20 2 datasets

Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap

Motif DE_72h DE_72h-TBX20_MA0689.1 11 bp overlap

TBX21 2 datasets

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

Motif DE_72h DE_72h-TBX21_MA0690.3 10 bp overlap

TBX3 2 datasets

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

Motif DE_72h DE_72h-TBX3_MA1566.3 9 bp overlap

TBX4 2 datasets

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

Motif DE_72h DE_72h-TBX4_MA0806.1 8 bp overlap

TBX5 2 datasets

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

Motif DE_72h DE_72h-TBX5_MA0807.1 8 bp overlap

TBXT 2 datasets

Motif DE_60h DE_60h-TBXT_MA0009.2 16 bp overlap

Motif DE_72h DE_72h-TBXT_MA0009.2 16 bp overlap

TCF12 3 datasets

Motif DE_48h DE_48h-TCF12_MA1648.2 7 bp overlap

Motif DE_60h DE_60h-TCF12_MA1648.2 7 bp overlap

Motif DE_72h DE_72h-TCF12_MA1648.2 7 bp overlap

TCF3 3 datasets

Motif DE_48h DE_48h-TCF3_MA0522.4 7 bp overlap

Motif DE_60h DE_60h-TCF3_MA0522.4 7 bp overlap

Motif DE_72h DE_72h-TCF3_MA0522.4 7 bp overlap

TCF4 2 datasets

ChIP GEN2-2 GSE76147.TCF4.GEN2-2 192 bp overlap

ChIP GEN2-2 GSE76147.TCF4.GEN2-2 163 bp overlap

ChIP GM06170 GSE55727.TP53.GM06170 206 bp overlap

Tbx6 2 datasets

Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap

Motif DE_72h DE_72h-Tbx6_MA1567.3 9 bp overlap

ZBTB38 1 dataset

ChIP HepG2 ENCFF875UQX 521 bp overlap

ZEB1 3 datasets

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ZFP14 1 dataset

Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap

ZNF257 2 datasets

Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap

Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap

ZNF317 1 dataset

ChIP HEK293 GSE76494.ZNF317.HEK293 260 bp overlap

ZNF324 1 dataset

Motif DE_48h DE_48h-ZNF324_MA1977.2 14 bp overlap

ZNF582 1 dataset

Motif DE_48h DE_48h-ZNF582_MA1983.2 19 bp overlap

ZNF687 1 dataset

ChIP HepG2 ENCFF653WIX 771 bp overlap

ZNF93 3 datasets

Motif DE_48h DE_48h-ZNF93_MA1721.2 14 bp overlap

Motif DE_60h DE_60h-ZNF93_MA1721.2 14 bp overlap

Motif DE_72h DE_72h-ZNF93_MA1721.2 14 bp overlap

Zic1::Zic2 3 datasets

Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap

Zic3 3 datasets

Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap

Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap

Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap