This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by cognitive disability, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GATM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:45,117,740–45,118,422 | 260.5 kb | Distal (>10kb) Multiome | 509 | |
| chr15:45,162,761–45,163,531 | 215.5 kb | Distal (>10kb) Multiome HiCAR | 392 | |
| chr15:45,166,561–45,167,807 | 211.3 kb | Distal (>10kb) Multiome HiCAR | 718 | |
| chr15:45,186,761–45,188,736 | 190.7 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr15:45,198,102–45,201,508 | 178.2 kb | Distal (>10kb) Multiome HiCAR | 1170 | |
| chr15:45,224,322–45,226,044 | 153.9 kb | Distal (>10kb) Multiome | 242 | |
| chr15:45,278,955–45,279,690 | 99.4 kb | Distal (>10kb) Multiome | 613 | |
| chr15:45,376,152–45,377,230 | 2.2 kb | Proximal (<10kb) Multiome | 97 | |
| chr15:45,378,041–45,378,887 | 267 bp | At TSS Multiome | 372 | |
| chr15:45,399,702–45,399,867 | 2.5 kb | Proximal (<10kb) | 92 | |
| chr15:45,401,783–45,403,544 | 23.6 kb | Distal (>10kb) Multiome | 903 | |
| chr15:45,471,908–45,473,344 | 93.7 kb | Distal (>10kb) Multiome | 124 | |
| chr15:45,522,020–45,523,300 | 144.0 kb | Distal (>10kb) Multiome | 511 | |
| chr15:45,573,841–45,574,674 | 195.5 kb | Distal (>10kb) Multiome | 166 | |
| chr15:45,583,788–45,584,651 | 205.3 kb | Distal (>10kb) Multiome | 249 | |
| chr15:45,586,825–45,587,849 | 208.6 kb | Distal (>10kb) Multiome | 1004 | |
| chr15:45,634,437–45,635,635 | 256.3 kb | Distal (>10kb) Multiome | 739 |
Genomic view of the GATM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.