Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC30A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC30A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC30A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:45,224,322–45,226,044 | 297.9 kb | Distal (>10kb) Multiome | 242 | |
| chr15:45,278,955–45,279,690 | 243.4 kb | Distal (>10kb) Multiome | 613 | |
| chr15:45,376,152–45,377,230 | 146.2 kb | Distal (>10kb) Multiome | 97 | |
| chr15:45,378,041–45,378,887 | 144.3 kb | Distal (>10kb) Multiome | 372 | |
| chr15:45,401,783–45,403,544 | 120.4 kb | Distal (>10kb) Multiome | 903 | |
| chr15:45,471,908–45,473,344 | 50.3 kb | Distal (>10kb) Multiome | 124 | |
| chr15:45,522,020–45,523,300 | 38 bp | At TSS Multiome | 511 | |
| chr15:45,573,841–45,574,674 | 51.5 kb | Distal (>10kb) Multiome | 166 | |
| chr15:45,583,788–45,584,651 | 61.3 kb | Distal (>10kb) Multiome | 249 | |
| chr15:45,586,825–45,587,849 | 64.6 kb | Distal (>10kb) Multiome | 1004 | |
| chr15:45,634,437–45,635,635 | 112.3 kb | Distal (>10kb) Multiome | 739 | |
| chr15:45,704,015–45,705,263 | 181.7 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the SLC30A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.