Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:45,022,392–45,023,983 | 178.0 kb | Distal (>10kb) Multiome | 755 | |
| chr15:45,035,231–45,035,688 | 165.7 kb | Distal (>10kb) Multiome | 12 | |
| chr15:45,048,481–45,049,541 | 152.1 kb | Distal (>10kb) Multiome | 334 | |
| chr15:45,112,418–45,113,157 | 88.2 kb | Distal (>10kb) Multiome | 97 | |
| chr15:45,117,740–45,118,422 | 82.9 kb | Distal (>10kb) Multiome | 509 | |
| chr15:45,129,270–45,130,268 | 71.3 kb | Distal (>10kb) Multiome | 118 | |
| chr15:45,162,761–45,163,531 | 37.9 kb | Distal (>10kb) Multiome | 392 | |
| chr15:45,166,561–45,167,807 | 33.7 kb | Distal (>10kb) Multiome | 718 | |
| chr15:45,186,761–45,188,736 | 13.1 kb | Distal (>10kb) Multiome | 506 | |
| chr15:45,198,102–45,201,508 | 578 bp | At TSS Multiome | 1170 | |
| chr15:45,205,199–45,205,446 | 4.1 kb | Proximal (<10kb) | 193 | |
| chr15:45,224,322–45,226,044 | 23.7 kb | Distal (>10kb) Multiome | 242 | |
| chr15:45,278,955–45,279,690 | 78.2 kb | Distal (>10kb) Multiome HiCAR | 613 | |
| chr15:45,376,152–45,377,230 | 175.4 kb | Distal (>10kb) Multiome | 97 | |
| chr15:45,378,041–45,378,887 | 177.4 kb | Distal (>10kb) Multiome | 372 | |
| chr15:45,401,783–45,403,544 | 201.2 kb | Distal (>10kb) Multiome HiCAR | 903 | |
| chr15:45,471,908–45,473,344 | 271.3 kb | Distal (>10kb) Multiome | 124 |
Genomic view of the SHF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.