The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for DUOX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUOX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUOX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:45,022,392–45,023,983 | 106.9 kb | Distal (>10kb) Multiome | 755 | |
| chr15:45,035,231–45,035,688 | 94.6 kb | Distal (>10kb) Multiome | 12 | |
| chr15:45,048,481–45,049,541 | 81.0 kb | Distal (>10kb) Multiome | 334 | |
| chr15:45,117,740–45,118,422 | 11.8 kb | Distal (>10kb) Multiome | 509 | |
| chr15:45,129,270–45,130,268 | at TSS | At TSS | 118 | |
| chr15:45,135,258–45,135,607 | 5.3 kb | Proximal (<10kb) | 54 | |
| chr15:45,136,533–45,136,691 | 6.5 kb | Proximal (<10kb) | 35 | |
| chr15:45,162,761–45,163,531 | 33.2 kb | Distal (>10kb) Multiome | 392 | |
| chr15:45,166,561–45,167,807 | 37.4 kb | Distal (>10kb) Multiome | 718 | |
| chr15:45,186,761–45,188,736 | 58.1 kb | Distal (>10kb) Multiome | 506 | |
| chr15:45,198,102–45,201,508 | 70.5 kb | Distal (>10kb) Multiome | 1170 | |
| chr15:45,224,322–45,226,044 | 94.9 kb | Distal (>10kb) Multiome | 242 | |
| chr15:45,278,955–45,279,690 | 149.3 kb | Distal (>10kb) Multiome | 613 | |
| chr15:45,376,152–45,377,230 | 246.6 kb | Distal (>10kb) Multiome | 97 | |
| chr15:45,378,041–45,378,887 | 248.5 kb | Distal (>10kb) Multiome | 372 | |
| chr15:45,401,783–45,403,544 | 272.4 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the DUOX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.