Transcription factors with Perturb-seq knockdown data for ENSG00000259539. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259539 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259539, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:45,022,392–45,023,983 | 144.4 kb | Distal (>10kb) Multiome | 755 | |
| chr15:45,035,231–45,035,688 | 132.1 kb | Distal (>10kb) Multiome | 12 | |
| chr15:45,048,481–45,049,541 | 118.5 kb | Distal (>10kb) Multiome | 334 | |
| chr15:45,117,740–45,118,422 | 49.3 kb | Distal (>10kb) Multiome | 509 | |
| chr15:45,162,761–45,163,531 | 4.3 kb | Proximal (<10kb) Multiome | 392 | |
| chr15:45,166,561–45,167,807 | 110 bp | At TSS Multiome | 718 | |
| chr15:45,186,761–45,188,736 | 20.5 kb | Distal (>10kb) Multiome | 506 | |
| chr15:45,198,102–45,201,508 | 33.0 kb | Distal (>10kb) Multiome | 1170 | |
| chr15:45,224,322–45,226,044 | 57.3 kb | Distal (>10kb) Multiome | 242 | |
| chr15:45,278,955–45,279,690 | 111.8 kb | Distal (>10kb) Multiome | 613 | |
| chr15:45,376,152–45,377,230 | 209.0 kb | Distal (>10kb) Multiome | 97 | |
| chr15:45,378,041–45,378,887 | 210.9 kb | Distal (>10kb) Multiome | 372 | |
| chr15:45,401,783–45,403,544 | 234.8 kb | Distal (>10kb) Multiome HiCAR | 903 |
Genomic view of the ENSG00000259539 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.