This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for TBX20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBX20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBX20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:35,036,664–35,038,744 | 216.4 kb | Distal (>10kb) Multiome | 804 | |
| chr7:35,185,645–35,187,217 | 67.9 kb | Distal (>10kb) Multiome | 274 | |
| chr7:35,248,647–35,249,942 | 5.0 kb | Proximal (<10kb) Multiome | 358 | |
| chr7:35,253,386–35,255,107 | 47 bp | At TSS Multiome | 357 | |
| chr7:35,256,280–35,256,865 | 2.2 kb | Proximal (<10kb) | 76 | |
| chr7:35,257,289–35,258,565 | 3.2 kb | Proximal (<10kb) | 119 | |
| chr7:35,259,307–35,259,512 | 5.2 kb | Proximal (<10kb) | 16 | |
| chr7:35,261,015–35,262,351 | 7.8 kb | Proximal (<10kb) Multiome | 217 | |
| chr7:35,263,294–35,263,692 | 9.2 kb | Proximal (<10kb) | 24 | |
| chr7:35,301,809–35,303,376 | 48.3 kb | Distal (>10kb) Multiome | 85 | |
| chr7:35,331,849–35,332,680 | 78.1 kb | Distal (>10kb) Multiome | 175 | |
| chr7:35,390,142–35,390,653 | 136.3 kb | Distal (>10kb) Multiome HiCAR | 109 | |
| chr7:35,537,034–35,537,920 | 283.5 kb | Distal (>10kb) Multiome HiCAR | 411 | |
| chr7:35,624,084–35,625,028 | 370.5 kb | Distal (>10kb) Multiome HiCAR | 320 |
Genomic view of the TBX20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.