This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for TBX15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBX15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBX15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:118,979,509–118,980,074 | 8.3 kb | Proximal (<10kb) | 101 | |
| chr1:118,983,179–118,983,898 | 4.4 kb | Proximal (<10kb) | 59 | |
| chr1:118,984,102–118,984,918 | 3.4 kb | Proximal (<10kb) | 178 | |
| chr1:118,985,031–118,985,676 | 2.7 kb | Proximal (<10kb) | 42 | |
| chr1:118,987,197–118,988,726 | at TSS | At TSS | 267 | |
| chr1:118,988,890–118,989,213 | 547 bp | At TSS | 36 | |
| chr1:118,989,341–118,990,505 | 998 bp | At TSS | 137 | |
| chr1:118,991,588–118,992,249 | 3.2 kb | Proximal (<10kb) | 27 | |
| chr1:118,993,028–118,993,553 | 4.7 kb | Proximal (<10kb) | 107 |
Genomic view of the TBX15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.