TBX19

T-box transcription factor 19 | TPIT, dj747L4.1

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]

Biological processes 24 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)anatomical structure morphogenesis (GO:0009653)cell fate specification (GO:0001708)chromatin (GO:0000785)chromatin (GO:0000785)cis-regulatory region sequence-specific DNA binding (GO:0000987)heart morphogenesis (GO:0003007)mesoderm formation (GO:0001707)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating TBX19 0 TFs

Transcription factors with Perturb-seq knockdown data for TBX19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBX19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TBX19

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBX19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:168,082,150–168,082,782	208.7 kb	Distal (>10kb) Multiome	282
chr1:168,135,686–168,137,665	154.3 kb	Distal (>10kb) Multiome	557
chr1:168,145,525–168,146,368	145.2 kb	Distal (>10kb) Multiome	327
chr1:168,146,489–168,147,203	144.3 kb	Distal (>10kb) Multiome	155
chr1:168,178,414–168,179,583	112.3 kb	Distal (>10kb) Multiome	940
chr1:168,187,044–168,187,988	103.7 kb	Distal (>10kb) Multiome	107
chr1:168,225,447–168,226,729	65.2 kb	Distal (>10kb) Multiome	1005

Genome Browser

Genomic view of the TBX19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.