The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for RAD51. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD51 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD51, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,405,523–40,406,103 | 289.4 kb | Distal (>10kb) Multiome | 672 | |
| chr15:40,440,664–40,441,222 | 254.3 kb | Distal (>10kb) Multiome | 440 | |
| chr15:40,470,654–40,471,315 | 224.2 kb | Distal (>10kb) Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 183.4 kb | Distal (>10kb) Multiome | 646 | |
| chr15:40,593,777–40,594,776 | 101.1 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 130 bp | At TSS Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 60.1 kb | Distal (>10kb) Multiome | 816 | |
| chr15:40,763,848–40,764,563 | 68.9 kb | Distal (>10kb) Multiome | 799 | |
| chr15:40,806,990–40,807,956 | 112.4 kb | Distal (>10kb) Multiome | 782 | |
| chr15:40,843,756–40,844,502 | 149.0 kb | Distal (>10kb) Multiome | 364 | |
| chr15:40,873,588–40,874,396 | 178.8 kb | Distal (>10kb) Multiome | 556 | |
| chr15:40,893,927–40,894,547 | 199.2 kb | Distal (>10kb) Multiome | 741 | |
| chr15:40,906,419–40,906,902 | 211.4 kb | Distal (>10kb) Multiome | 630 | |
| chr15:40,941,651–40,942,174 | 246.8 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 258.2 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the RAD51 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.