chr12:8,911,603–8,912,126

chr12 : 8,911,603 – 8,912,126

523 bp 92 TFs 7 linked genes

This 523 bp open chromatin element is linked to 7 target genes and is bound by 92 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PHC1		1.8 kb	Proximal	Proximity
ENSG00000282022		3.1 kb	Proximal	Proximity
M6PR		37.8 kb	Distal	Multiome
KLRG1		38.1 kb	Distal	Multiome
A2ML1		88.4 kb	Distal	Multiome
LINC02972		123.7 kb	Distal	Multiome
RIMKLB		230.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

92 transcription factors

ARID1A 1 dataset

ChIP HAP1 GSE108387.ARID1A.HAP1 341 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 523 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 440 bp overlap

ATF2 2 datasets

ChIP H1 ENCFF295GZO 397 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 327 bp overlap

Arid3a 1 dataset

Motif DE_12h DE_12h-Arid3a_MA0151.1 6 bp overlap

BCL11A 4 datasets

ChIP H1 ENCFF833IPY 114 bp overlap

ChIP H1 ENCFF836SSR 144 bp overlap

ChIP WA01 ENCSR000BIP.BCL11A.WA01 117 bp overlap

ChIP WA01 ENCSR000BMJ.BCL11A.WA01 108 bp overlap

BCOR 2 datasets

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 228 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 243 bp overlap

CEBPB 1 dataset

ChIP WA01 ENCSR000EBV.CEBPB.WA01 135 bp overlap

CEBPG 1 dataset

ChIP K562 ENCFF956TPS 85 bp overlap

CHD1 3 datasets

ChIP H1 ENCFF128BID 135 bp overlap

ChIP H1 ENCFF998XEK 104 bp overlap

ChIP WA01 ENCSR000EBU.CHD1.WA01 271 bp overlap

CHD2 2 datasets

ChIP H1 ENCFF991MKH 143 bp overlap

ChIP WA01 ENCSR000EBT.CHD2.WA01 294 bp overlap

CHD7 2 datasets

ChIP H1 ENCFF126NLU 264 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 523 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 269 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF798NMV 52 bp overlap

Motif DE_12h DE_12h-Crx_MA0467.3 6 bp overlap

Dmbx1 1 dataset

Motif DE_12h DE_12h-Dmbx1_MA0883.2 10 bp overlap

ChIP MUTUL GSE75503.EBF1.MUTUL 122 bp overlap

EOMES 3 datasets

Motif DE_12h DE_12h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 237 bp overlap

ChIP hESC GSE26097.EOMES.hESC 164 bp overlap

EP300 3 datasets

ChIP H1 ENCFF927IYK 185 bp overlap

ChIP WA01 ENCSR000BKK.EP300.WA01 249 bp overlap

ChIP hESC GSE17917.EP300.hESC 514 bp overlap

ESRRB 1 dataset

Motif DE_12h DE_12h-ESRRB_MA0141.4 10 bp overlap

ETS1 3 datasets

ChIP GM23338 ENCFF701IZH 377 bp overlap

ChIP GM23338 ENCFF701IZH 239 bp overlap

ChIP hESC ENCSR534VHI.ETS1.hESC 138 bp overlap

ETV2::FIGLA 1 dataset

Motif DE_12h DE_12h-ETV2FIGLA_MA1941.2 13 bp overlap

ETV5::FIGLA 1 dataset

Motif DE_12h DE_12h-ETV5FIGLA_MA1945.2 14 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FOXA2 1 dataset

ChIP BJ1-hTERT_MimoRelease GSE92491.FOXA2.BJ1-hTERT_MimoRelease 198 bp overlap

FOXP1 1 dataset

ChIP H9 GSE31006.FOXP1.H9 173 bp overlap

GATA4 1 dataset

ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 307 bp overlap

Motif DE_12h DE_12h-GSC_MA0648.2 6 bp overlap

Motif DE_12h DE_12h-GSC2_MA0891.2 6 bp overlap

HDAC2 3 datasets

ChIP H1 ENCFF353UJQ 417 bp overlap

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 234 bp overlap

Motif DE_12h DE_12h-Hmx2_MA0897.2 15 bp overlap

Motif DE_12h DE_12h-Isl1_MA1608.2 7 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 523 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 523 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 523 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 311 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 523 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 523 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 523 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 523 bp overlap

ChIP WA01 ENCSR000EBZ.JUND.WA01 410 bp overlap

KLF4 2 datasets

ChIP HAP1 GSE130417.KLF4.HAP1 112 bp overlap

ChIP WA09 GSE105028.KLF4.WA09 167 bp overlap

MAFK 2 datasets

ChIP H1 ENCFF854XWE 142 bp overlap

ChIP WA01 ENCSR000EBS.MAFK.WA01 135 bp overlap

ChIP P493-6 GSE36354.MAX.P493-6 203 bp overlap

ChIP WA01 ENCSR000EUP.MAX.WA01 269 bp overlap

MED1 2 datasets

ChIP G296S_4 GSE85628.MED1.G296S_4 81 bp overlap

ChIP hESC_PRIMED GSE69646.MED1.hESC_PRIMED 523 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 312 bp overlap

ChIP Jurkat GSE59657.MYB.Jurkat 151 bp overlap

ChIP PF-382 GSE94000.MYB.PF-382 152 bp overlap

MYOD1 1 dataset

Motif DE_12h DE_12h-MYOD1_MA0499.3 9 bp overlap

NANOG 12 datasets

ChIP GM23338 ENCFF065NZG 177 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 523 bp overlap

ChIP H1 ENCFF747ZPQ 169 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 523 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 523 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 200 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 199 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 523 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 523 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 523 bp overlap

ChIP hESC GSE18292.NANOG.hESC 373 bp overlap

ChIP hESC GSE20650.NANOG.hESC 333 bp overlap

NIPBL 3 datasets

ChIP hESC GSE64758.NIPBL.hESC 259 bp overlap

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 264 bp overlap

ChIP hESC_activin GSE64758.NIPBL.hESC_activin 201 bp overlap

NR1H4::RXRA 1 dataset

Motif DE_12h DE_12h-NR1H4RXRA_MA1146.2 13 bp overlap

Nfat5 1 dataset

Motif DE_12h DE_12h-Nfat5_MA0606.3 8 bp overlap

Motif DE_12h DE_12h-OTX1_MA0711.2 6 bp overlap

ChIP WTC11 ENCFF634NAO 188 bp overlap

PITX1 1 dataset

Motif DE_12h DE_12h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_12h DE_12h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_12h DE_12h-PITX3_MA0714.2 6 bp overlap

POLR2A 2 datasets

ChIP H1 ENCFF566JSR 493 bp overlap

ChIP H1 ENCFF770YBQ 391 bp overlap

POU3F3 1 dataset

Motif DE_12h DE_12h-POU3F3_MA0788.1 13 bp overlap

POU5F1 17 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 505 bp overlap

ChIP GM23338 ENCFF333SNB 83 bp overlap

ChIP H1 ENCFF698ZAP 171 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 523 bp overlap

ChIP NCCIT GSE36134.POU5F1.NCCIT 431 bp overlap

ChIP WA01 ENCSR000BMU.POU5F1.WA01 176 bp overlap

ChIP WA01 ENCSR000BMU.POU5F1.WA01 209 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 189 bp overlap

ChIP WA09 GSE105028.POU5F1.WA09 478 bp overlap

ChIP WA09_heat-shock GSE105028.POU5F1.WA09_heat-shock 521 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 174 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 190 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 523 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 523 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 251 bp overlap

ChIP hiPSC GSE149017.POU5F1.hiPSC 173 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 172 bp overlap

Motif DE_12h DE_12h-RARA_MA0729.1 18 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 156 bp overlap

RHOXF1 1 dataset

Motif DE_12h DE_12h-RHOXF1_MA0719.2 6 bp overlap

ChIP JMSU-1 GSE107734.RXRA.JMSU-1 228 bp overlap

SCRT1 1 dataset

Motif DE_12h DE_12h-SCRT1_MA0743.3 10 bp overlap

SCRT2 1 dataset

Motif DE_12h DE_12h-SCRT2_MA0744.3 10 bp overlap

SIN3A 1 dataset

ChIP WA01 ENCSR000EBO.SIN3A.WA01 242 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 435 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 326 bp overlap

SMAD2_3 1 dataset

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 183 bp overlap

SMAD3 4 datasets

ChIP BG03 GSE21614.SMAD3.BG03 154 bp overlap

ChIP BG03 GSE21614.SMAD3.BG03 191 bp overlap

ChIP BG03_DIFF_0H GSE36578.SMAD3.BG03_DIFF_0H 184 bp overlap

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 165 bp overlap

SMARCA4 3 datasets

ChIP WA09 GSE105028.SMARCA4.WA09 209 bp overlap

ChIP WA09_heat-shock GSE105028.SMARCA4.WA09_heat-shock 523 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 523 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 523 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 523 bp overlap

SMARCC1 3 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 520 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 523 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 523 bp overlap

SNAI2 1 dataset

Motif DE_12h DE_12h-SNAI2_MA0745.3 8 bp overlap

SOX2 5 datasets

ChIP H9 GSE46837.SOX2.H9 160 bp overlap

ChIP hESC GSE69479.SOX2.hESC 173 bp overlap

ChIP hESC GSE18292.SOX2.hESC 111 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 226 bp overlap

ChIP hiPSC_3s2 GSE81899.SOX2.hiPSC_3s2 287 bp overlap

ChIP H1 ENCFF263FUH 192 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 481 bp overlap

ChIP WTC11 ENCFF688PEU 457 bp overlap

ChIP WTC11 ENCFF688PEU 257 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 160 bp overlap

ChIP H1 ENCFF036PEF 225 bp overlap

ChIP WA01 ENCSR000BIV.SRF.WA01 225 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 209 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 258 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 286 bp overlap

ChIP hESC GSE122298.TBP.hESC 516 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 101 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 174 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 523 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 79 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 247 bp overlap

Motif DE_12h DE_12h-TBR1_MA0802.2 9 bp overlap

TBX18 1 dataset

Motif DE_12h DE_12h-TBX18_MA1565.2 9 bp overlap

Motif DE_12h DE_12h-TBX2_MA0688.2 9 bp overlap

Motif DE_12h DE_12h-TBX3_MA1566.3 9 bp overlap

TCF12 2 datasets

ChIP H1 ENCFF203EBH 179 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 215 bp overlap

ChIP NPC GSE154479.TCF3.NPC 523 bp overlap

TEAD1 4 datasets

ChIP HUCCT1 GSE68296.TEAD1.HUCCT1 230 bp overlap

ChIP WTC11 ENCFF502QUV 287 bp overlap

ChIP keratinocyte GSE138727.TEAD1.keratinocyte 211 bp overlap

ChIP pancreas_12D ERP008682.TEAD1.pancreas_12D 149 bp overlap

TEAD4 6 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 366 bp overlap

ChIP PC-9_1DF GSE131687.TEAD4.PC-9_1DF 357 bp overlap

ChIP PC-9_1DF_DMSO GSE131687.TEAD4.PC-9_1DF_DMSO 373 bp overlap

ChIP PC-9_2DF GSE131687.TEAD4.PC-9_2DF 400 bp overlap

ChIP PC-9_2DF_DMSO GSE131687.TEAD4.PC-9_2DF_DMSO 399 bp overlap

ChIP hESC GSE99202.TEAD4.hESC 407 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 314 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_12h DE_12h-TFAP4FLI1_MA1967.2 14 bp overlap

TP53 2 datasets

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 457 bp overlap

ChIP H9_mesoderm GSE142050.TP53.H9_mesoderm 319 bp overlap

Motif DE_12h DE_12h-Tbx6_MA1567.3 9 bp overlap

ChIP ALL GSE145549.YY1.ALL 409 bp overlap

ChIP NT2-D1 ENCSR000EXG.YY1.NT2-D1 154 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 463 bp overlap

YY1AP1 3 datasets

ChIP PC-9_1DF GSE131687.YY1AP1.PC-9_1DF 385 bp overlap

ChIP PC-9_1DF_DMSO GSE131687.YY1AP1.PC-9_1DF_DMSO 270 bp overlap

ChIP PC-9_2DF GSE131687.YY1AP1.PC-9_2DF 452 bp overlap

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZMAT4 1 dataset

ChIP WTC11 ENCFF608UXZ 194 bp overlap

ZNF189 1 dataset

Motif DE_12h DE_12h-ZNF189_MA1725.2 9 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 460 bp overlap

ZNF416 1 dataset

ChIP WTC11 ENCFF407TAZ 271 bp overlap