Predicted to enable N-acetyl-L-aspartate-L-glutamate ligase activity and citrate-L-glutamate ligase activity. Predicted to be involved in glutamine family amino acid metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIMKLB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIMKLB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIMKLB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:8,396,290–8,396,965 | 284.8 kb | Distal (>10kb) Multiome | 59 | |
| chr12:8,589,422–8,590,041 | 91.8 kb | Distal (>10kb) Multiome | 36 | |
| chr12:8,635,736–8,636,521 | 45.5 kb | Distal (>10kb) Multiome | 57 | |
| chr12:8,639,004–8,640,552 | 41.6 kb | Distal (>10kb) Multiome | 163 | |
| chr12:8,681,398–8,681,768 | at TSS | At TSS | 154 | |
| chr12:8,682,162–8,682,313 | 563 bp | At TSS | 149 | |
| chr12:8,692,636–8,692,895 | 5.0 kb | Proximal (<10kb) | 179 | |
| chr12:8,697,096–8,698,824 | 16.3 kb | Distal (>10kb) Multiome | 624 | |
| chr12:8,699,601–8,699,996 | 1.7 kb | Proximal (<10kb) | 61 | |
| chr12:8,804,682–8,805,722 | 123.5 kb | Distal (>10kb) Multiome | 77 | |
| chr12:8,809,981–8,810,589 | 128.8 kb | Distal (>10kb) Multiome | 18 | |
| chr12:8,819,132–8,819,867 | 137.8 kb | Distal (>10kb) Multiome | 194 | |
| chr12:8,911,603–8,912,126 | 230.3 kb | Distal (>10kb) Multiome | 92 | |
| chr12:8,913,876–8,915,422 | 233.0 kb | Distal (>10kb) Multiome HiCAR | 537 | |
| chr12:8,948,926–8,950,657 | 268.3 kb | Distal (>10kb) Multiome | 936 |
Genomic view of the RIMKLB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.