This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PHC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:8,635,736–8,636,521 | 277.8 kb | Distal (>10kb) Multiome | 57 | |
| chr12:8,639,004–8,640,552 | 273.9 kb | Distal (>10kb) Multiome | 163 | |
| chr12:8,697,096–8,698,824 | 216.0 kb | Distal (>10kb) Multiome | 624 | |
| chr12:8,804,682–8,805,722 | 108.8 kb | Distal (>10kb) Multiome | 77 | |
| chr12:8,809,981–8,810,589 | 103.5 kb | Distal (>10kb) Multiome | 18 | |
| chr12:8,819,132–8,819,867 | 94.5 kb | Distal (>10kb) Multiome | 194 | |
| chr12:8,911,603–8,912,126 | 2.0 kb | Proximal (<10kb) Multiome | 92 | |
| chr12:8,913,876–8,915,422 | 668 bp | At TSS Multiome | 537 | |
| chr12:8,948,926–8,950,657 | 36.0 kb | Distal (>10kb) Multiome | 936 | |
| chr12:9,030,629–9,031,494 | 117.1 kb | Distal (>10kb) Multiome HiCAR | 38 | |
| chr12:9,064,208–9,065,913 | 151.2 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the PHC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.