Transcription factors with Perturb-seq knockdown data for ENSG00000282022. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000282022 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000282022, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:8,635,736–8,636,521 | 279.4 kb | Distal (>10kb) Multiome | 57 | |
| chr12:8,697,096–8,698,824 | 217.4 kb | Distal (>10kb) Multiome | 624 | |
| chr12:8,809,981–8,810,589 | 104.9 kb | Distal (>10kb) Multiome | 18 | |
| chr12:8,819,132–8,819,867 | 95.8 kb | Distal (>10kb) Multiome | 194 | |
| chr12:8,911,603–8,912,126 | 3.4 kb | Proximal (<10kb) Multiome | 92 | |
| chr12:8,913,876–8,915,422 | 755 bp | At TSS Multiome | 537 | |
| chr12:8,948,926–8,950,657 | 34.6 kb | Distal (>10kb) Multiome | 936 | |
| chr12:9,064,208–9,065,913 | 149.8 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the ENSG00000282022 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.