Transcription factors with Perturb-seq knockdown data for LINC02972. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02972 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02972, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:8,589,422–8,590,041 | 198.4 kb | Distal (>10kb) Multiome | 36 | |
| chr12:8,635,736–8,636,521 | 152.2 kb | Distal (>10kb) Multiome | 57 | |
| chr12:8,639,004–8,640,552 | 148.2 kb | Distal (>10kb) Multiome | 163 | |
| chr12:8,697,096–8,698,824 | 90.4 kb | Distal (>10kb) Multiome | 624 | |
| chr12:8,788,840–8,789,205 | 587 bp | At TSS | 10 | |
| chr12:8,804,682–8,805,722 | 16.8 kb | Distal (>10kb) Multiome | 77 | |
| chr12:8,809,981–8,810,589 | 22.1 kb | Distal (>10kb) Multiome | 18 | |
| chr12:8,819,132–8,819,867 | 31.2 kb | Distal (>10kb) Multiome | 194 | |
| chr12:8,911,603–8,912,126 | 123.7 kb | Distal (>10kb) Multiome | 92 | |
| chr12:8,913,876–8,915,422 | 126.3 kb | Distal (>10kb) Multiome | 537 | |
| chr12:8,948,926–8,950,657 | 161.6 kb | Distal (>10kb) Multiome | 936 | |
| chr12:9,030,629–9,031,494 | 242.8 kb | Distal (>10kb) Multiome | 38 | |
| chr12:9,064,208–9,065,913 | 276.9 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the LINC02972 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.