Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for KLRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:8,697,096–8,698,824 | 252.2 kb | Distal (>10kb) Multiome | 624 | |
| chr12:8,804,682–8,805,722 | 144.9 kb | Distal (>10kb) Multiome | 77 | |
| chr12:8,809,981–8,810,589 | 139.7 kb | Distal (>10kb) Multiome | 18 | |
| chr12:8,819,132–8,819,867 | 130.6 kb | Distal (>10kb) Multiome | 194 | |
| chr12:8,911,603–8,912,126 | 38.1 kb | Distal (>10kb) Multiome | 92 | |
| chr12:8,913,876–8,915,422 | 35.5 kb | Distal (>10kb) Multiome | 537 | |
| chr12:8,948,926–8,950,657 | 156 bp | At TSS Multiome | 936 | |
| chr12:9,030,629–9,031,494 | 81.0 kb | Distal (>10kb) Multiome HiCAR | 38 | |
| chr12:9,064,208–9,065,913 | 115.1 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the KLRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.