The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for CEBPG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEBPG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEBPG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:33,080,776–33,081,465 | 292.6 kb | Distal (>10kb) Multiome | 838 | |
| chr19:33,124,582–33,125,060 | 248.8 kb | Distal (>10kb) Multiome | 321 | |
| chr19:33,176,278–33,177,966 | 196.6 kb | Distal (>10kb) Multiome | 1077 | |
| chr19:33,193,912–33,194,503 | 179.5 kb | Distal (>10kb) Multiome | 256 | |
| chr19:33,225,334–33,226,211 | 148.0 kb | Distal (>10kb) Multiome | 146 | |
| chr19:33,226,520–33,227,396 | 146.6 kb | Distal (>10kb) Multiome HiCAR | 219 | |
| chr19:33,301,181–33,303,965 | 71.0 kb | Distal (>10kb) Multiome | 945 | |
| chr19:33,373,183–33,374,325 | 61 bp | At TSS Multiome | 871 | |
| chr19:33,406,730–33,407,310 | 33.3 kb | Distal (>10kb) Multiome | 393 | |
| chr19:33,520,926–33,522,397 | 148.2 kb | Distal (>10kb) Multiome | 747 | |
| chr19:33,621,458–33,623,467 | 248.2 kb | Distal (>10kb) Multiome | 384 | |
| chr19:33,777,882–33,778,531 | 404.5 kb | Distal (>10kb) Multiome HiCAR | 668 | |
| chr19:34,134,218–34,135,012 | 760.8 kb | Distal (>10kb) Multiome HiCAR | 833 |
Genomic view of the CEBPG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.