chr12:8,227,234–8,228,048

chr12 : 8,227,234 – 8,228,048

814 bp 86 TFs 10 linked genes

This 814 bp open chromatin element is linked to 10 target genes and is bound by 86 transcription factors.

Linked Genes

10 genes

Gene	Expression	Dist. to TSS	Distance	Link type
FAM90A1		at TSS	At TSS	Proximity
ALG1L10P		at TSS	At TSS	Proximity
LINC02449		7.4 kb	Proximal	Proximity
ENSG00000275367		9.5 kb	Proximal	Proximity
ENSG00000286895		15.6 kb	Distal	Multiome
FAM66C		47.3 kb	Distal	Multiome
NECAP1		145.3 kb	Distal	Multiome
LINC00937		163.2 kb	Distal	Multiome
FOXJ2		194.2 kb	Distal	Multiome
SLC2A3		291.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

86 transcription factors

ARID3B 1 dataset

ChIP K562 ENCFF224SWC 305 bp overlap

ARID4B 1 dataset

ChIP K562 ENCFF791HBV 621 bp overlap

ASCL1 2 datasets

Motif ES_0h ES_0h-ASCL1_MA1100.3 8 bp overlap

Motif ES_0h ES_0h-ASCL1_MA1631.2 9 bp overlap

ChIP GM12878 ENCFF037PYH 203 bp overlap

ChIP GM12878 ENCFF954REE 53 bp overlap

BCL11A 1 dataset

ChIP GM12878 ENCFF717YPR 92 bp overlap

BHLHE22 1 dataset

Motif ES_0h ES_0h-BHLHE22_MA1635.2 6 bp overlap

BHLHE40 1 dataset

ChIP GM12878 ENCFF521IZR 405 bp overlap

BORCS8-MEF2B,MEF2B 2 datasets

ChIP GM12878 ENCFF427QAI 271 bp overlap

ChIP GM12878 ENCFF427QAI 472 bp overlap

ChIP hESC GSE33281.BRD4.hESC 68 bp overlap

CREB3L1 2 datasets

ChIP K562 ENCFF701TVD 551 bp overlap

ChIP K562 ENCFF701TVD 425 bp overlap

CTCF 4 datasets

Motif DE_12h DE_12h-CTCF_MA1929.2 31 bp overlap

Motif ES_0h ES_0h-CTCF_MA1929.2 31 bp overlap

ChIP MM1-S GSE43743.CTCF.MM1-S 231 bp overlap

ChIP neutrophil ENCFF770HHA 268 bp overlap

ChIP GM12878 ENCFF681AJV 66 bp overlap

ChIP K-562 ENCSR000EWJ.E2F6.K-562 157 bp overlap

ChIP K562 ENCFF622HMZ 342 bp overlap

ChIP GM12878 ENCFF266FYW 221 bp overlap

ChIP GM12878 ENCFF692SMY 296 bp overlap

EP400 2 datasets

ChIP K562 ENCFF850OZQ 703 bp overlap

ChIP K562 ENCFF850OZQ 503 bp overlap

ChIP SKNO-1 GSE23730.ERG.SKNO-1 360 bp overlap

ChIP TSU-1621MT GSE60477.ERG.TSU-1621MT 168 bp overlap

Motif DE_12h DE_12h-ESR2_MA0258.2 15 bp overlap

ETV5::FIGLA 1 dataset

Motif ES_0h ES_0h-ETV5FIGLA_MA1945.2 14 bp overlap

FIGLA 1 dataset

Motif ES_0h ES_0h-FIGLA_MA0820.2 6 bp overlap

ChIP SKNO-1 GSE23730.FLI1.SKNO-1 563 bp overlap

FOXP1 1 dataset

ChIP K562 ENCFF954SDY 367 bp overlap

GATAD2B 1 dataset

ChIP GM12878 ENCFF781IAU 304 bp overlap

HDAC1 1 dataset

ChIP K562 ENCFF968WBH 142 bp overlap

IKZF1 2 datasets

ChIP GM12878 ENCFF753XDO 170 bp overlap

ChIP GM12878 ENCFF824TGK 374 bp overlap

IKZF2 1 dataset

ChIP GM12878 ENCFF238LYK 308 bp overlap

ChIP GM12878 ENCSR000BGY.IRF4.GM12878 98 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 309 bp overlap

ChIP GM12878 ENCFF667EJQ 94 bp overlap

ChIP GM12878 ENCFF086GAB 94 bp overlap

ChIP K562 ENCFF175ZTN 462 bp overlap

L3MBTL2 1 dataset

ChIP K562 ENCFF320EQC 397 bp overlap

MAX 15 datasets

ChIP GM12878 ENCFF849VCQ 421 bp overlap

ChIP HCT116 ENCFF810LEN 497 bp overlap

ChIP K-562 ENCSR000FAE.MAX.K-562 191 bp overlap

ChIP K-562 ENCSR000EFV.MAX.K-562 109 bp overlap

ChIP K562 ENCFF110LJS 351 bp overlap

ChIP K562 ENCFF398VJM 476 bp overlap

ChIP K562 ENCFF398VJM 537 bp overlap

ChIP K562 ENCFF524IJO 240 bp overlap

ChIP NB4 ENCFF966MWB 277 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 235 bp overlap

ChIP P493-6 GSE42262.MAX.P493-6 262 bp overlap

ChIP P493-6 GSE36354.MAX.P493-6 366 bp overlap

ChIP P493-6_24HR GSE125863.MAX.P493-6_24HR 323 bp overlap

ChIP P493-6_CMYC_1H GSE36354.MAX.P493-6_CMYC_1H 261 bp overlap

ChIP endothelial_umbilical-vein ENCSR000EEZ.MAX.endothelial_umbilical-vein 114 bp overlap

ChIP GM12878 ENCFF453CES 457 bp overlap

ChIP K562 ENCFF140CEX 585 bp overlap

ChIP K562 ENCFF342DNS 419 bp overlap

ChIP K562 ENCFF342DNS 426 bp overlap

ChIP K562 ENCFF450LDL 444 bp overlap

ChIP K562 ENCFF820IGH 529 bp overlap

ChIP GM12878 ENCFF615CWQ 298 bp overlap

ChIP K-562 ENCSR000FAG.MYC.K-562 109 bp overlap

ChIP K562 ENCFF988ZRU 437 bp overlap

ChIP MM1-S_DMSO GSE36354.MYC.MM1-S_DMSO 175 bp overlap

ChIP NB4 ENCFF142PRP 317 bp overlap

ChIP P493-6 GSE77061.MYC.P493-6 539 bp overlap

ChIP P493-6_SHCTR GSE60223.MYC.P493-6_SHCTR 122 bp overlap

NR2C1 2 datasets

ChIP GM12878 ENCFF101ELO 357 bp overlap

ChIP K562 ENCFF239KMA 501 bp overlap

NR2C2 2 datasets

Motif DE_12h DE_12h-NR2C2_MA0504.2 14 bp overlap

ChIP K562 ENCFF750AXF 727 bp overlap

NR2F1 3 datasets

Motif DE_12h DE_12h-NR2F1_MA1537.2 13 bp overlap

ChIP GM12878 ENCFF273VKX 354 bp overlap

ChIP GM12878 ENCFF273VKX 505 bp overlap

Neurod2 1 dataset

Motif ES_0h ES_0h-Neurod2_MA1993.2 6 bp overlap

Nr2f6 1 dataset

Motif DE_12h DE_12h-Nr2f6_MA0677.2 13 bp overlap

Olig2 1 dataset

Motif ES_0h ES_0h-Olig2_MA1997.2 6 bp overlap

ChIP K562 ENCFF217UCA 285 bp overlap

POLR2A 4 datasets

ChIP body of pancreas ENCFF501FEC 500 bp overlap

ChIP body of pancreas ENCFF501FEC 142 bp overlap

ChIP body of pancreas ENCFF727UBE 437 bp overlap

ChIP spleen ENCFF446ZGT 219 bp overlap

POLR2G 2 datasets

ChIP K562 ENCFF047BLG 207 bp overlap

ChIP K562 ENCFF047BLG 498 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 468 bp overlap

PPARA::RXRA 1 dataset

Motif DE_12h DE_12h-PPARARXRA_MA1148.2 17 bp overlap

PPARD 1 dataset

Motif DE_12h DE_12h-PPARD_MA1550.2 14 bp overlap

Pparg::Rxra 1 dataset

Motif DE_12h DE_12h-PpargRxra_MA0065.3 13 bp overlap

Prdm15 1 dataset

Motif ES_0h ES_0h-Prdm15_MA1616.2 11 bp overlap

RAD51 2 datasets

ChIP GM12878 ENCFF916JXQ 229 bp overlap

ChIP K562 ENCFF133ELP 124 bp overlap

RBFOX2 5 datasets

ChIP K-562 ENCSR822LBD.RBFOX2.K-562 242 bp overlap

ChIP K-562 GSE120104.RBFOX2.K-562 242 bp overlap

ChIP K562 ENCFF196WTG 776 bp overlap

ChIP K562 ENCFF967GRF 339 bp overlap

ChIP K562 ENCFF967GRF 389 bp overlap

RUNX1T1 1 dataset

ChIP Kasumi-1 GSE43834.RUNX1T1.Kasumi-1 173 bp overlap

RUNX3 1 dataset

ChIP GM12878 ENCFF395WHA 141 bp overlap

Motif DE_12h DE_12h-RXRB_MA0855.1 14 bp overlap

Motif DE_12h DE_12h-RXRG_MA0856.1 14 bp overlap

Motif DE_12h DE_12h-Rxra_MA0512.2 14 bp overlap

SAP30 1 dataset

ChIP K562 ENCFF652WJB 485 bp overlap

SNAI1 1 dataset

Motif ES_0h ES_0h-SNAI1_MA1558.2 7 bp overlap

SNAI2 1 dataset

Motif ES_0h ES_0h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif ES_0h ES_0h-SNAI3_MA1559.2 9 bp overlap

SPI1 5 datasets

ChIP GM12878 ENCFF134LCP 109 bp overlap

ChIP GM12891 ENCFF563IUT 71 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 99 bp overlap

ChIP HL-60 ENCFF645GBT 103 bp overlap

ChIP K562 ENCFF410ORC 67 bp overlap

TCF12 4 datasets

Motif ES_0h ES_0h-TCF12_MA1648.2 7 bp overlap

ChIP GM12878 ENCFF433DMU 175 bp overlap

ChIP GM12878 ENCFF506WWB 96 bp overlap

ChIP GM12878 ENCSR000BGZ.TCF12.GM12878 334 bp overlap

TCF3 7 datasets

Motif ES_0h ES_0h-TCF3_MA0522.4 7 bp overlap

ChIP GM12878 ENCFF658WIO 224 bp overlap

ChIP GM12878 ENCFF658WIO 297 bp overlap

ChIP GM12878 ENCSR000BQT.TCF3.GM12878 69 bp overlap

ChIP GM12878 ENCSR000BQT.TCF3.GM12878 162 bp overlap

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 165 bp overlap

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 155 bp overlap

Motif ES_0h ES_0h-TCF4_MA0830.3 8 bp overlap

TFAP2A 1 dataset

Motif ES_0h ES_0h-TFAP2A_MA0003.5 9 bp overlap

TFAP2B 2 datasets

Motif ES_0h ES_0h-TFAP2B_MA0811.2 11 bp overlap

Motif ES_0h ES_0h-TFAP2B_MA0812.2 9 bp overlap

TFAP2C 2 datasets

Motif ES_0h ES_0h-TFAP2C_MA0524.3 11 bp overlap

Motif ES_0h ES_0h-TFAP2C_MA0814.3 9 bp overlap

TFAP2E 1 dataset

Motif ES_0h ES_0h-TFAP2E_MA1569.2 9 bp overlap

TFAP4 1 dataset

ChIP K562 ENCFF727PXG 545 bp overlap

Motif DE_12h DE_12h-THRB_MA1574.2 13 bp overlap

Tcf12 1 dataset

Motif ES_0h ES_0h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif ES_0h ES_0h-Twist2_MA0633.3 6 bp overlap

USF1 5 datasets

ChIP GM12878 ENCFF880HJL 257 bp overlap

ChIP GM12878 ENCSR000BGI.USF1.GM12878 110 bp overlap

ChIP GM12878 ENCSR000BGI.USF1.GM12878 154 bp overlap

ChIP K562 ENCFF202SFC 425 bp overlap

ChIP K562 ENCFF633EZB 265 bp overlap

USF2 2 datasets

ChIP GM12878 GSE97661.USF2.GM12878 145 bp overlap

ChIP K562 ENCFF397QGU 265 bp overlap

VEZF1 1 dataset

ChIP K562 ENCFF053XDV 497 bp overlap

ChIP GM12878 ENCFF908JTL 345 bp overlap

ChIP GM12891 ENCFF460SIS 325 bp overlap

ChIP GM12892 ENCSR000BLT.YY1.GM12892 140 bp overlap

ChIP NT2-D1 ENCSR000EXG.YY1.NT2-D1 122 bp overlap

Motif ES_0h ES_0h-YY2_MA0748.3 7 bp overlap

ZBTB9 1 dataset

ChIP K562 ENCFF233EFX 344 bp overlap

Motif ES_0h ES_0h-ZEB1_MA0103.4 6 bp overlap

ChIP K562 ENCFF169LZT 651 bp overlap

ChIP K562 ENCFF169LZT 470 bp overlap

ChIP K562 ENCFF536AJO 757 bp overlap

ChIP K562 ENCFF536AJO 558 bp overlap

ZNF24 1 dataset

ChIP GM12878 ENCFF688STO 67 bp overlap