Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose import across plasma membrane; galactose transmembrane transport; and transport across blood-brain barrier. Located in aggresome and plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC2A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC2A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC2A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:7,638,028–7,638,994 | 297.5 kb | Distal (>10kb) Multiome | 360 | |
| chr12:7,639,859–7,640,636 | 295.8 kb | Distal (>10kb) Multiome | 28 | |
| chr12:7,709,770–7,710,489 | 226.1 kb | Distal (>10kb) Multiome | 82 | |
| chr12:7,859,953–7,860,905 | 75.8 kb | Distal (>10kb) Multiome | 344 | |
| chr12:7,906,949–7,907,466 | 28.9 kb | Distal (>10kb) Multiome | 435 | |
| chr12:7,933,254–7,933,739 | 2.4 kb | Proximal (<10kb) | 386 | |
| chr12:7,935,022–7,936,948 | 130 bp | At TSS Multiome | 450 | |
| chr12:7,937,904–7,938,471 | 1.9 kb | Proximal (<10kb) Multiome | 193 | |
| chr12:7,959,506–7,960,170 | 23.6 kb | Distal (>10kb) Multiome | 284 | |
| chr12:7,960,785–7,961,174 | 24.7 kb | Distal (>10kb) Multiome | 471 | |
| chr12:7,970,302–7,971,168 | 34.7 kb | Distal (>10kb) Multiome | 619 | |
| chr12:7,994,878–7,995,556 | 59.1 kb | Distal (>10kb) Multiome HiCAR | 262 | |
| chr12:8,018,686–8,019,483 | 82.9 kb | Distal (>10kb) Multiome | 217 | |
| chr12:8,026,338–8,027,323 | 90.7 kb | Distal (>10kb) Multiome | 935 | |
| chr12:8,032,354–8,033,866 | 96.5 kb | Distal (>10kb) Multiome | 673 | |
| chr12:8,081,804–8,082,716 | 146.0 kb | Distal (>10kb) Multiome | 840 | |
| chr12:8,227,234–8,228,048 | 291.4 kb | Distal (>10kb) Multiome | 86 |
Genomic view of the SLC2A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.