The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for CREB3L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREB3L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREB3L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,120,416–46,122,472 | 173.6 kb | Distal (>10kb) Multiome | 758 | |
| chr11:46,238,964–46,239,736 | 55.8 kb | Distal (>10kb) Multiome | 559 | |
| chr11:46,242,857–46,244,010 | 51.6 kb | Distal (>10kb) Multiome HiCAR | 900 | |
| chr11:46,277,351–46,278,874 | 16.5 kb | Distal (>10kb) Multiome | 343 | |
| chr11:46,290,653–46,290,937 | 4.2 kb | Proximal (<10kb) | 125 | |
| chr11:46,294,934–46,295,998 | 460 bp | At TSS Multiome | 533 | |
| chr11:46,296,747–46,297,460 | 2.0 kb | Proximal (<10kb) Multiome | 415 | |
| chr11:46,338,698–46,339,679 | 44.1 kb | Distal (>10kb) Multiome | 393 | |
| chr11:46,346,987–46,348,092 | 52.2 kb | Distal (>10kb) Multiome | 586 | |
| chr11:46,352,002–46,352,557 | 57.3 kb | Distal (>10kb) Multiome | 306 | |
| chr11:46,379,120–46,383,444 | 86.6 kb | Distal (>10kb) Multiome | 930 | |
| chr11:46,388,459–46,390,750 | 94.5 kb | Distal (>10kb) Multiome | 593 | |
| chr11:46,391,139–46,393,221 | 96.7 kb | Distal (>10kb) Multiome | 965 | |
| chr11:46,593,562–46,594,345 | 298.8 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the CREB3L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.