Transcription factors with Perturb-seq knockdown data for LINC00937. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00937 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00937, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:8,227,234–8,228,048 | 163.2 kb | Distal (>10kb) Multiome | 86 | |
| chr12:8,242,239–8,244,415 | 147.4 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr12:8,317,343–8,317,958 | 73.0 kb | Distal (>10kb) Multiome | 109 | |
| chr12:8,389,958–8,390,426 | at TSS | At TSS | 25 | |
| chr12:8,390,509–8,390,808 | 172 bp | At TSS | 66 | |
| chr12:8,396,290–8,396,965 | 6.0 kb | Proximal (<10kb) Multiome | 59 | |
| chr12:8,589,422–8,590,041 | 199.1 kb | Distal (>10kb) Multiome | 36 | |
| chr12:8,635,736–8,636,521 | 245.3 kb | Distal (>10kb) Multiome | 57 | |
| chr12:8,639,004–8,640,552 | 249.3 kb | Distal (>10kb) Multiome | 163 |
Genomic view of the LINC00937 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.