This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ESR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:64,060,545–64,061,040 | 233.6 kb | Distal (>10kb) Multiome | 204 | |
| chr14:64,186,206–64,187,022 | 107.9 kb | Distal (>10kb) Multiome | 106 | |
| chr14:64,293,957–64,295,260 | 551 bp | At TSS Multiome | 474 | |
| chr14:64,303,449–64,303,757 | 9.0 kb | Proximal (<10kb) | 137 | |
| chr14:64,337,827–64,339,391 | 44.4 kb | Distal (>10kb) Multiome | 825 | |
| chr14:64,387,230–64,388,939 | 93.7 kb | Distal (>10kb) Multiome | 902 | |
| chr14:64,391,271–64,391,891 | 97.1 kb | Distal (>10kb) Multiome | 182 | |
| chr14:64,465,087–64,466,161 | 171.1 kb | Distal (>10kb) Multiome | 490 | |
| chr14:64,502,980–64,505,716 | 209.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr14:64,508,924–64,509,409 | 214.8 kb | Distal (>10kb) Multiome | 117 | |
| chr14:64,539,520–64,541,644 | 246.1 kb | Distal (>10kb) Multiome | 722 | |
| chr14:64,549,785–64,550,422 | 255.6 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the ESR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.