Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FOXJ2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXJ2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXJ2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:7,859,953–7,860,905 | 173.0 kb | Distal (>10kb) Multiome HiCAR | 344 | |
| chr12:7,906,949–7,907,466 | 126.1 kb | Distal (>10kb) Multiome | 435 | |
| chr12:7,935,022–7,936,948 | 97.0 kb | Distal (>10kb) Multiome | 450 | |
| chr12:7,937,904–7,938,471 | 95.2 kb | Distal (>10kb) Multiome | 193 | |
| chr12:7,959,506–7,960,170 | 73.5 kb | Distal (>10kb) Multiome | 284 | |
| chr12:7,960,785–7,961,174 | 72.4 kb | Distal (>10kb) Multiome | 471 | |
| chr12:7,970,302–7,971,168 | 62.5 kb | Distal (>10kb) Multiome | 619 | |
| chr12:7,994,878–7,995,556 | 38.1 kb | Distal (>10kb) Multiome | 262 | |
| chr12:8,018,686–8,019,483 | 14.3 kb | Distal (>10kb) Multiome | 217 | |
| chr12:8,026,338–8,027,323 | 6.5 kb | Proximal (<10kb) Multiome | 935 | |
| chr12:8,027,509–8,027,695 | 5.0 kb | Proximal (<10kb) | 84 | |
| chr12:8,032,354–8,033,866 | 657 bp | At TSS Multiome | 673 | |
| chr12:8,038,700–8,039,088 | 6.0 kb | Proximal (<10kb) | 244 | |
| chr12:8,081,804–8,082,716 | 48.8 kb | Distal (>10kb) Multiome | 840 | |
| chr12:8,227,234–8,228,048 | 194.2 kb | Distal (>10kb) Multiome | 86 | |
| chr12:8,242,239–8,244,415 | 210.0 kb | Distal (>10kb) Multiome | 348 | |
| chr12:8,317,343–8,317,958 | 284.3 kb | Distal (>10kb) Multiome | 109 |
Genomic view of the FOXJ2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.