chr5:43,000,993–43,001,324

chr5 : 43,000,993 – 43,001,324

331 bp 75 TFs 4 linked genes

This 331 bp open chromatin element is linked to 4 target genes and is bound by 75 transcription factors.

Linked Genes

4 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000286656		5.9 kb	Proximal	Proximity
ENSG00000289206		6.0 kb	Proximal	Proximity
ENSG00000271788		6.2 kb	Proximal	Proximity
ENSG00000287263		8.2 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

75 transcription factors

ChIP MCF-7_TCDD_45min GSE90550.AHR.MCF-7_TCDD_45min 125 bp overlap

ChIP HCT-116 GSE103894.APC.HCT-116 195 bp overlap

ARID1A 1 dataset

ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 90 bp overlap

ChIP MCF-7_Ctrl GSE85352.ARNT.MCF-7_Ctrl 168 bp overlap

ASH2L 1 dataset

ChIP Hep-G2 ENCSR508LMH.ASH2L.Hep-G2 130 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 233 bp overlap

BRD2 5 datasets

ChIP HCC1806_BAZ2B_JQ1 GSE116879.BRD2.HCC1806_BAZ2B_JQ1 81 bp overlap

ChIP HCC1806_BAZ2BsiRNA GSE116879.BRD2.HCC1806_BAZ2BsiRNA 227 bp overlap

ChIP HCC1806_NTsiRNA GSE116879.BRD2.HCC1806_NTsiRNA 308 bp overlap

ChIP HCC1806_NTsiRNA_JQ1 GSE116879.BRD2.HCC1806_NTsiRNA_JQ1 264 bp overlap

ChIP MDA-MB-231_BAZ2AsiRNA GSE116879.BRD2.MDA-MB-231_BAZ2AsiRNA 70 bp overlap

BRD4 3 datasets

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 100 bp overlap

ChIP HCC1806_100nMtrametinib_24h GSE87418.BRD4.HCC1806_100nMtrametinib_24h 146 bp overlap

ChIP SEM GSE83671.BRD4.SEM 315 bp overlap

ChIP MOLM-14_IBET GSE65138.CDK8.MOLM-14_IBET 135 bp overlap

ChIP T-47D GSE62428.CHD8.T-47D 160 bp overlap

CREB1 5 datasets

ChIP MCF-7 ENCFF867SAS 229 bp overlap

ChIP MCF-7 ENCSR897JAS.CREB1.MCF-7 175 bp overlap

ChIP MCF-7 ENCSR620DUQ.CREB1.MCF-7 183 bp overlap

ChIP MDA-MB-134-VI_FI GSE109103.CREB1.MDA-MB-134-VI_FI 125 bp overlap

ChIP WA01 ENCSR000BSN.CREB1.WA01 97 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF093OYK 295 bp overlap

ChIP BLaER1 ENCFF335XTP 100 bp overlap

DEAF1 1 dataset

ChIP keratinocyte GSE129965.DEAF1.keratinocyte 192 bp overlap

ChIP ProEs GSE59087.EED.ProEs 135 bp overlap

ELF3 3 datasets

ChIP PDAC GSE64557.ELF3.PDAC 290 bp overlap

ChIP PDAC_KOKLF5 GSE64557.ELF3.PDAC_KOKLF5 177 bp overlap

ChIP PDAC_SHCTR GSE64557.ELF3.PDAC_SHCTR 331 bp overlap

ESR1 2 datasets

ChIP MCF-7_E2_45m GSE67295.ESR1.MCF-7_E2_45m 162 bp overlap

ChIP primary-endometrium-cancer_E1_DSG GSE114737.ESR1.primary-endometrium-cancer_E1_DSG 148 bp overlap

EZH2 6 datasets

ChIP RCH-ACV GSE135024.EZH2.RCH-ACV 331 bp overlap

ChIP fibroblast of lung ENCFF479BAW 176 bp overlap

ChIP hepatocyte ENCSR384LYW.EZH2.hepatocyte 254 bp overlap

ChIP neural progenitor cell ENCFF018MKA 331 bp overlap

ChIP neural progenitor cell ENCFF472NFV 254 bp overlap

ChIP neural progenitor cell ENCFF472NFV 262 bp overlap

EZH2_phosphoT487 2 datasets

ChIP hepatocyte ENCSR341VYI.EZH2_phosphoT487.hepatocyte 215 bp overlap

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 172 bp overlap

FOXA1 7 datasets

ChIP CFPAC-1_FOXA2-KO GSE119930.FOXA1.CFPAC-1_FOXA2-KO 101 bp overlap

ChIP MCF-7_DOX-neg GSE124654.FOXA1.MCF-7_DOX-neg 117 bp overlap

ChIP MCF-7_JC4690 GSE126004.FOXA1.MCF-7_JC4690 132 bp overlap

ChIP breast-cancer_ENOB-2852 GSE128018.FOXA1.breast-cancer_ENOB-2852 137 bp overlap

ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 210 bp overlap

ChIP breast-cancer_Veh-2858 GSE128018.FOXA1.breast-cancer_Veh-2858 237 bp overlap

ChIP primary-prostate-cancer_P2_DSG GSE114737.FOXA1.primary-prostate-cancer_P2_DSG 152 bp overlap

FOXA2 3 datasets

ChIP CFPAC-1 GSE119930.FOXA2.CFPAC-1 141 bp overlap

ChIP CFPAC-1_EV GSE119930.FOXA2.CFPAC-1_EV 186 bp overlap

ChIP CFPAC-1_HOXB8-OE GSE119930.FOXA2.CFPAC-1_HOXB8-OE 264 bp overlap

GFI1 2 datasets

ChIP HepG2 ENCFF472INF 102 bp overlap

ChIP THP-1 GSE90769.GFI1.THP-1 304 bp overlap

GFI1B 2 datasets

ChIP CD34 GSE52924.GFI1B.CD34 209 bp overlap

ChIP HEK293 ENCFF264FBS 289 bp overlap

GRHL2 1 dataset

ChIP MCF-7 GSE109820.GRHL2.MCF-7 214 bp overlap

HDAC1 1 dataset

ChIP HepG2 ENCFF304IEJ 128 bp overlap

HDAC2 2 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 221 bp overlap

ChIP K562 ENCFF744ALD 329 bp overlap

INO80 1 dataset

ChIP Huh-7 GSE97411.INO80.Huh-7 240 bp overlap

ChIP PDAC GSE64557.IRF1.PDAC 160 bp overlap

ChIP HepG2 ENCFF742RIP 51 bp overlap

JARID2 3 datasets

ChIP AMIPS8 GSE48516.JARID2.AMIPS8 232 bp overlap

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 277 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 307 bp overlap

ChIP MCF-7_DMSO GSE157385.JUN.MCF-7_DMSO 272 bp overlap

ChIP MCF-7_abemaciclib GSE157385.JUN.MCF-7_abemaciclib 203 bp overlap

ChIP WA01 ENCSR000BKP.JUND.WA01 127 bp overlap

KDM4C 1 dataset

ChIP KYSE-150 GSE53938.KDM4C.KYSE-150 173 bp overlap

KDM5B 2 datasets

ChIP HCC2157 GSE46055.KDM5B.HCC2157 153 bp overlap

ChIP HepG2 ENCFF706LUI 53 bp overlap

ChIP keratinocyte GSE140991.KLF3.keratinocyte 173 bp overlap

ChIP PDAC GSE64557.KLF6.PDAC 227 bp overlap

KMT2A 2 datasets

ChIP MOLM-13_DMSO-D3-180110 GSE127507.KMT2A.MOLM-13_DMSO-D3-180110 331 bp overlap

ChIP SHI-1 GSE95511.KMT2A.SHI-1 163 bp overlap

ChIP HepG2 ENCFF507HCX 51 bp overlap

ChIP MCF-7 ENCSR000BUL.MAX.MCF-7 107 bp overlap

ChIP SEM GSE83671.MED.SEM 331 bp overlap

MED1 2 datasets

ChIP MCF-7_SHRARS GSE60270.MED1.MCF-7_SHRARS 241 bp overlap

ChIP MCF-7_SHRARS_E2 GSE60270.MED1.MCF-7_SHRARS_E2 163 bp overlap

ChIP SEM GSE83671.MEN1.SEM 145 bp overlap

ChIP HepG2 ENCFF057YJE 331 bp overlap

ChIP MCF-7 ENCSR000DMQ.MYC.MCF-7 130 bp overlap

NR3C1 1 dataset

ChIP HCC1937 GSE152203.NR3C1.HCC1937 98 bp overlap

ChIP HepG2 ENCFF694NVY 79 bp overlap

PCGF2 1 dataset

ChIP NT2-D1 GSE101538.PCGF2.NT2-D1 183 bp overlap

ChIP HepG2 ENCFF065NWR 79 bp overlap

PRDM15 2 datasets

ChIP Hep-G2 ENCSR011INW.PRDM15.Hep-G2 154 bp overlap

ChIP WTC11 ENCFF108TMF 331 bp overlap

RBM39 2 datasets

ChIP HepG2 ENCFF084YZE 76 bp overlap

ChIP HepG2 ENCFF801JUH 54 bp overlap

RCOR1 1 dataset

ChIP keratinocyte_diff GSE57702.RCOR1.keratinocyte_diff 64 bp overlap

RNF2 2 datasets

ChIP HUES-64 GSE104059.RNF2.HUES-64 179 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 331 bp overlap

Motif DE_12h DE_12h-Rfx6_MA1724.2 9 bp overlap

SMAD2 1 dataset

Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap

SMAD2-3 1 dataset

ChIP HGrC1_EV GSE138496.SMAD2-3.HGrC1_EV 113 bp overlap

SMAD3 2 datasets

ChIP NCI-H441 GSE51509.SMAD3.NCI-H441 186 bp overlap

ChIP NCI-H441_SIITTF1 GSE51509.SMAD3.NCI-H441_SIITTF1 251 bp overlap

SMARCA4 3 datasets

ChIP A-549_AG15685 GSE132290.SMARCA4.A-549_AG15685 248 bp overlap

ChIP A-549_AG15689 GSE132290.SMARCA4.A-549_AG15689 81 bp overlap

ChIP MCF-7 GSE140185.SMARCA4.MCF-7 216 bp overlap

SMARCB1 2 datasets

ChIP MCF-7 GSE123284.SMARCB1.MCF-7 85 bp overlap

ChIP MCF-7_estrogen GSE123284.SMARCB1.MCF-7_estrogen 108 bp overlap

SNAI2 1 dataset

ChIP PC-9_1DF GSE131687.SNAI2.PC-9_1DF 122 bp overlap

ChIP A-549 ENCSR000BPE.SP1.A-549 147 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 232 bp overlap

ChIP HEK293 ENCSR807LQP.SP2.HEK293 72 bp overlap

SPDEF 1 dataset

ChIP A-549 GSE86957.SPDEF.A-549 229 bp overlap

STAT3 4 datasets

ChIP MCF-7_jc5838 GSE126004.STAT3.MCF-7_jc5838 58 bp overlap

ChIP MCF-7_jc5843 GSE126004.STAT3.MCF-7_jc5843 137 bp overlap

ChIP MCF-7_jc5844 GSE126004.STAT3.MCF-7_jc5844 179 bp overlap

ChIP MCF-7_jc5846 GSE126004.STAT3.MCF-7_jc5846 205 bp overlap

SUZ12 2 datasets

ChIP H1 ENCFF881NFR 331 bp overlap

ChIP NT2-D1 GSE101538.SUZ12.NT2-D1 80 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 80 bp overlap

TEAD4 4 datasets

ChIP PC-9_1DF GSE131687.TEAD4.PC-9_1DF 170 bp overlap

ChIP PC-9_1DF_DMSO GSE131687.TEAD4.PC-9_1DF_DMSO 199 bp overlap

ChIP PC-9_2DF GSE131687.TEAD4.PC-9_2DF 159 bp overlap

ChIP PC-9_2DF_DMSO GSE131687.TEAD4.PC-9_2DF_DMSO 213 bp overlap

YY1AP1 4 datasets

ChIP PC-9_1DF GSE131687.YY1AP1.PC-9_1DF 263 bp overlap

ChIP PC-9_1DF_DMSO GSE131687.YY1AP1.PC-9_1DF_DMSO 94 bp overlap

ChIP PC-9_2DF GSE131687.YY1AP1.PC-9_2DF 258 bp overlap

ChIP PC-9_2DF_DMSO GSE131687.YY1AP1.PC-9_2DF_DMSO 123 bp overlap

ZBTB40 1 dataset

ChIP MCF-7 ENCSR318LVG.ZBTB40.MCF-7 57 bp overlap

ChIP HepG2 ENCFF808RQT 138 bp overlap

ZIM3 2 datasets

Motif DE_12h DE_12h-ZIM3_MA1709.2 11 bp overlap

ChIP HEK293 GSE76494.ZIM3.HEK293 144 bp overlap

ZNF143 1 dataset

ChIP HeLa GSE39263.ZNF143.HeLa 214 bp overlap

ZNF300 1 dataset

ChIP HEK293T GSE78099.ZNF300.HEK293T 91 bp overlap

ZNF335 1 dataset

ChIP HEK293 ENCFF784SLD 268 bp overlap

ZNF341 1 dataset

ChIP HEK293 GSE76494.ZNF341.HEK293 131 bp overlap

ZNF407 1 dataset

ChIP Hep-G2 ENCSR005WGY.ZNF407.Hep-G2 142 bp overlap

ZNF660 1 dataset

ChIP HEK293 ENCSR283DOU.ZNF660.HEK293 75 bp overlap

ZNF707 3 datasets

ChIP HEK293 ENCFF249FMX 237 bp overlap

ChIP HEK293 ENCSR854IPI.ZNF707.HEK293 221 bp overlap

ChIP HEK293T GSE78099.ZNF707.HEK293T 131 bp overlap