Transcription factors with Perturb-seq knockdown data for ENSG00000287263. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287263 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287263, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:42,991,932–42,993,007 | at TSS | At TSS | 570 | |
| chr5:42,994,942–42,995,192 | 2.1 kb | Proximal (<10kb) | 573 | |
| chr5:43,000,136–43,000,886 | 7.3 kb | Proximal (<10kb) | 255 | |
| chr5:43,000,993–43,001,324 | 8.2 kb | Proximal (<10kb) | 75 |
Genomic view of the ENSG00000287263 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.