Transcription factors with Perturb-seq knockdown data for ENSG00000271788. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271788 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271788, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,000,136–43,000,886 | 6.7 kb | Proximal (<10kb) | 255 | |
| chr5:43,000,993–43,001,324 | 6.2 kb | Proximal (<10kb) | 75 | |
| chr5:43,007,445–43,008,850 | at TSS | At TSS | 862 | |
| chr5:43,010,087–43,010,939 | 2.5 kb | Proximal (<10kb) | 417 | |
| chr5:43,016,201–43,016,848 | 8.7 kb | Proximal (<10kb) | 194 | |
| chr5:43,017,299–43,018,875 | 9.8 kb | Proximal (<10kb) | 870 |
Genomic view of the ENSG00000271788 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.