Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:38,318,529–38,319,451 | 345.2 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr4:38,319,684–38,320,353 | 344.0 kb | Distal (>10kb) Multiome HiCAR | 472 | |
| chr4:38,489,064–38,489,939 | 174.7 kb | Distal (>10kb) Multiome | 119 | |
| chr4:38,654,313–38,654,733 | 9.5 kb | Proximal (<10kb) | 103 | |
| chr4:38,662,974–38,665,390 | 1.1 kb | Proximal (<10kb) Multiome | 759 | |
| chr4:38,666,747–38,667,842 | 3.0 kb | Proximal (<10kb) Multiome | 769 | |
| chr4:38,672,084–38,673,018 | 8.3 kb | Proximal (<10kb) Multiome | 382 | |
| chr4:38,723,814–38,724,694 | 60.2 kb | Distal (>10kb) Multiome | 170 | |
| chr4:38,753,004–38,753,507 | 89.0 kb | Distal (>10kb) Multiome | 401 | |
| chr4:38,867,290–38,868,855 | 203.5 kb | Distal (>10kb) Multiome | 597 |
Genomic view of the KLF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.