This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for KDM4C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDM4C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDM4C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:6,590,688–6,591,679 | 166.5 kb | Distal (>10kb) Multiome | 403 | |
| chr9:6,592,227–6,592,641 | 165.1 kb | Distal (>10kb) Multiome | 82 | |
| chr9:6,645,085–6,646,200 | 111.9 kb | Distal (>10kb) Multiome | 656 | |
| chr9:6,680,771–6,682,229 | 76.2 kb | Distal (>10kb) Multiome | 1070 | |
| chr9:6,692,445–6,693,412 | 64.8 kb | Distal (>10kb) Multiome | 196 | |
| chr9:6,703,765–6,704,853 | 53.3 kb | Distal (>10kb) Multiome | 655 | |
| chr9:6,715,763–6,716,690 | 41.5 kb | Distal (>10kb) Multiome | 613 | |
| chr9:6,757,043–6,759,285 | 200 bp | At TSS Multiome | 1099 | |
| chr9:6,771,611–6,772,338 | 14.3 kb | Distal (>10kb) Multiome | 180 | |
| chr9:6,776,647–6,777,775 | 19.5 kb | Distal (>10kb) Multiome | 152 | |
| chr9:6,779,316–6,780,772 | 22.2 kb | Distal (>10kb) Multiome | 389 | |
| chr9:6,788,081–6,789,168 | 31.1 kb | Distal (>10kb) Multiome | 445 | |
| chr9:7,052,473–7,053,130 | 295.2 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the KDM4C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.