This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]
Transcription factors with Perturb-seq knockdown data for MEN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,630,081–64,630,643 | 180.4 kb | Distal (>10kb) Multiome | 226 | |
| chr11:64,637,888–64,638,531 | 172.5 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,656,654–64,657,126 | 153.7 kb | Distal (>10kb) Multiome | 80 | |
| chr11:64,688,437–64,688,967 | 122.0 kb | Distal (>10kb) Multiome | 581 | |
| chr11:64,710,919–64,711,752 | 99.3 kb | Distal (>10kb) Multiome | 152 | |
| chr11:64,729,775–64,730,315 | 80.7 kb | Distal (>10kb) Multiome | 115 | |
| chr11:64,742,520–64,743,124 | 67.8 kb | Distal (>10kb) Multiome | 501 | |
| chr11:64,759,882–64,760,354 | 50.6 kb | Distal (>10kb) Multiome | 172 | |
| chr11:64,777,493–64,779,271 | 33.0 kb | Distal (>10kb) Multiome | 859 | |
| chr11:64,802,650–64,803,485 | 7.3 kb | Proximal (<10kb) Multiome | 522 | |
| chr11:64,803,588–64,804,111 | 6.6 kb | Proximal (<10kb) | 376 | |
| chr11:64,809,807–64,811,090 | 43 bp | At TSS Multiome | 702 | |
| chr11:64,844,075–64,845,264 | 34.1 kb | Distal (>10kb) Multiome | 645 | |
| chr11:64,846,953–64,847,598 | 36.6 kb | Distal (>10kb) Multiome | 509 | |
| chr11:64,877,434–64,879,352 | 68.0 kb | Distal (>10kb) Multiome | 980 | |
| chr11:64,887,785–64,888,374 | 77.3 kb | Distal (>10kb) Multiome | 633 | |
| chr11:64,916,057–64,917,940 | 106.7 kb | Distal (>10kb) Multiome | 873 | |
| chr11:64,924,041–64,924,916 | 113.7 kb | Distal (>10kb) Multiome | 808 | |
| chr11:64,971,835–64,972,454 | 161.5 kb | Distal (>10kb) Multiome | 265 | |
| chr11:65,013,538–65,014,838 | 203.3 kb | Distal (>10kb) Multiome | 980 | |
| chr11:65,027,243–65,027,944 | 216.9 kb | Distal (>10kb) Multiome | 851 | |
| chr11:65,040,595–65,041,884 | 230.4 kb | Distal (>10kb) Multiome | 838 | |
| chr11:65,083,636–65,084,788 | 273.5 kb | Distal (>10kb) Multiome | 898 | |
| chr11:65,095,834–65,097,052 | 285.8 kb | Distal (>10kb) Multiome | 1061 |
Genomic view of the MEN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.