chr2:74,426,172–74,426,842

chr2 : 74,426,172 – 74,426,842

670 bp 88 TFs 20 linked genes

This 670 bp open chromatin element is linked to 20 target genes and is bound by 88 transcription factors.

Linked Genes

20 genes

Gene	Expression	Dist. to TSS	Distance	Link type
WDR54		4.4 kb	Proximal	Proximity
ENSG00000159239		4.5 kb	Proximal	Proximity
C2orf81		4.6 kb	Proximal	Proximity
RTKN		15.8 kb	Distal	Multiome
INO80B		28.5 kb	Distal	Multiome
WBP1		31.8 kb	Distal	Multiome
DCTN1		34.7 kb	Distal	Multiome
ENSG00000286883		38.7 kb	Distal	Multiome
MOGS		38.8 kb	Distal	Multiome
CCDC142		56.4 kb	Distal	Multiome
TTC31		56.5 kb	Distal	Multiome
SLC4A5		92.4 kb	Distal	Multiome
AUP1		103.1 kb	Distal	Multiome
HTRA2		103.3 kb	Distal	Multiome
LOXL3		127.4 kb	Distal	Multiome
M1AP		221.7 kb	Distal	Multiome
MTHFD2		228.0 kb	Distal	Multiome
MOB1A		247.7 kb	Distal	Multiome
BOLA3		278.7 kb	Distal	Multiome
ENSG00000286739		288.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

88 transcription factors

AGO1 2 datasets

ChIP Hep-G2 ENCSR555ZMV.AGO1.Hep-G2 242 bp overlap

ChIP Hep-G2 GSE120104.AGO1.Hep-G2 242 bp overlap

AGO2 2 datasets

ChIP HepG2 ENCFF252VFI 569 bp overlap

ChIP HepG2 ENCFF773YDL 570 bp overlap

BMPR1A 1 dataset

ChIP HUVEC-C GSE60156.BMPR1A.HUVEC-C 268 bp overlap

BRD4 2 datasets

ChIP MCF-10A ERP003925.BRD4.MCF-10A 438 bp overlap

ChIP keratinocyte GSE140992.BRD4.keratinocyte 525 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 286 bp overlap

ChIP K562 ENCFF673OEZ 351 bp overlap

CCAR2 2 datasets

ChIP Hep-G2 ENCSR247XFV.CCAR2.Hep-G2 447 bp overlap

ChIP Hep-G2 GSE120104.CCAR2.Hep-G2 432 bp overlap

CSRNP1 1 dataset

ChIP HepG2 ENCFF191UYG 209 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF031ISE 260 bp overlap

ChIP BLaER1 ENCFF274GAT 426 bp overlap

DNMT3B 1 dataset

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 249 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 316 bp overlap

ESR1 7 datasets

ChIP MCF-7_SHCTR_E2_TNF GSE59530.ESR1.MCF-7_SHCTR_E2_TNF 195 bp overlap

ChIP MDA-MB-134-VI_E2 GSE109103.ESR1.MDA-MB-134-VI_E2 171 bp overlap

ChIP MDA-MB-231_LQ_45min GSE95121.ESR1.MDA-MB-231_LQ_45min 305 bp overlap

ChIP U2OS_100nM-E2 GSE151039.ESR1.U2OS_100nM-E2 352 bp overlap

ChIP U2OS_10nM-E2 GSE151039.ESR1.U2OS_10nM-E2 364 bp overlap

ChIP U2OS_10nM-E2-B GSE151039.ESR1.U2OS_10nM-E2-B 390 bp overlap

ChIP U2OS_E2 GSE26110.ESR1.U2OS_E2 155 bp overlap

ESR1_pS118 1 dataset

ChIP MCF-7_Veh_sc GSE117569.ESR1_pS118.MCF-7_Veh_sc 119 bp overlap

FIGLA 1 dataset

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

ChIP HCT-116_A7A GSE152144.FOS.HCT-116_A7A 428 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 493 bp overlap

ChIP DE DE-FOXA2-2 432 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 425 bp overlap

ChIP DE DE-GATA4-2 407 bp overlap

ChIP foregut GSE117136.GATA4.foregut 366 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 477 bp overlap

ChIP DE DE-GATA6-2 435 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 360 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 327 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 308 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 424 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 314 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 365 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 372 bp overlap

ChIP foregut GSE117136.GATA6.foregut 366 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 332 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 457 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 273 bp overlap

GLIS2 2 datasets

ChIP HEK293 ENCFF446EIF 511 bp overlap

ChIP HEK293 ENCSR535DIA.GLIS2.HEK293 468 bp overlap

HNRNPL 3 datasets

ChIP Hep-G2 GSE120104.HNRNPL.Hep-G2 489 bp overlap

ChIP Hep-G2 ENCSR315JJE.HNRNPL.Hep-G2 148 bp overlap

ChIP Hep-G2 ENCSR315JJE.HNRNPL.Hep-G2 282 bp overlap

IFNA1 2 datasets

ChIP Huh-7_GFP GSE110511.IFNA1.Huh-7_GFP 172 bp overlap

ChIP Huh-7_GFP GSE110511.IFNA1.Huh-7_GFP 331 bp overlap

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 407 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 397 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 389 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 492 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 275 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 507 bp overlap

KLF16 1 dataset

Motif DE_72h DE_72h-KLF16_MA0741.1 11 bp overlap

KLF17 2 datasets

ChIP HEK293 ENCFF658MHR 425 bp overlap

ChIP HEK293 ENCSR065WUF.KLF17.HEK293 470 bp overlap

ChIP HEK293_D418N GSE88976.KLF5.HEK293_D418N 311 bp overlap

ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 415 bp overlap

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 230 bp overlap

MED26 1 dataset

ChIP U2OS_SHEP400 GSE73742.MED26.U2OS_SHEP400 192 bp overlap

MEIS1 1 dataset

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

ChIP Hep-G2 ENCSR983KRB.MTA1.Hep-G2 361 bp overlap

MYOCD 1 dataset

ChIP A-549 GSE128921.MYOCD.A-549 468 bp overlap

MYOD1 2 datasets

Motif DE_72h DE_72h-MYOD1_MA0499.3 9 bp overlap

ChIP IMR-90_GM GSE128527.MYOD1.IMR-90_GM 357 bp overlap

ChIP RH30_DMSO GSE85169.MYOG.RH30_DMSO 205 bp overlap

NCAPH2 1 dataset

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 550 bp overlap

NELFE 1 dataset

ChIP K-562_NHS GSE112379.NELFE.K-562_NHS 208 bp overlap

ChIP HepG2 ENCFF528PUT 419 bp overlap

ChIP HCT-116_ab20662 GSE97527.PAF1.HCT-116_ab20662 596 bp overlap

PATZ1 2 datasets

ChIP HEK293 ENCFF016MNJ 521 bp overlap

ChIP HEK293 ENCSR966ULI.PATZ1.HEK293 448 bp overlap

Motif DE_72h DE_72h-PBX3_MA1114.2 11 bp overlap

PCBP1 5 datasets

ChIP Hep-G2 GSE120104.PCBP1.Hep-G2 438 bp overlap

ChIP Hep-G2 ENCSR872EVQ.PCBP1.Hep-G2 404 bp overlap

ChIP HepG2 ENCFF447SRJ 231 bp overlap

ChIP HepG2 ENCFF604TPT 231 bp overlap

ChIP HepG2 ENCFF604TPT 511 bp overlap

PCBP2 3 datasets

ChIP Hep-G2 GSE120104.PCBP2.Hep-G2 230 bp overlap

ChIP Hep-G2 ENCSR945NSF.PCBP2.Hep-G2 230 bp overlap

ChIP HepG2 ENCFF033VWK 147 bp overlap

PKNOX2 1 dataset

Motif DE_72h DE_72h-PKNOX2_MA0783.1 12 bp overlap

POLR2A 3 datasets

ChIP H1 ENCFF566JSR 131 bp overlap

ChIP HepG2 ENCFF718XAJ 273 bp overlap

ChIP spleen ENCFF706IUS 545 bp overlap

POLR2G 2 datasets

ChIP HepG2 ENCFF241AEG 670 bp overlap

ChIP HepG2 ENCFF508UTS 670 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 411 bp overlap

PTBP1 3 datasets

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 143 bp overlap

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 432 bp overlap

ChIP Hep-G2 GSE120104.PTBP1.Hep-G2 261 bp overlap

RBFOX2 1 dataset

ChIP HepG2 ENCFF939HTZ 510 bp overlap

RBM39 1 dataset

ChIP Hep-G2 GSE120104.RBM39.Hep-G2 188 bp overlap

RFX1 3 datasets

ChIP K-562 ENCSR968GIB.RFX1.K-562 64 bp overlap

ChIP K562 ENCFF809XVG 114 bp overlap

ChIP MCF-7 ENCSR066TET.RFX1.MCF-7 98 bp overlap

SIN3A 1 dataset

ChIP HCT116 ENCFF203YBB 293 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 390 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 588 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 372 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 360 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 306 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 272 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 489 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 540 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 306 bp overlap

SMARCA4 1 dataset

ChIP BIN-67_lentivirus-SMARCA4 GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4 230 bp overlap

SMARCB1 1 dataset

ChIP HeLa-S3 ENCSR000EDK.SMARCB1.HeLa-S3 189 bp overlap

SNAI2 1 dataset

Motif DE_72h DE_72h-SNAI2_MA0745.3 8 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 413 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

SREBF1 1 dataset

Motif DE_72h DE_72h-SREBF1_MA0829.3 10 bp overlap

SUPT5H 5 datasets

ChIP DLD-1_NELFCD-AID GSE144786.SUPT5H.DLD-1_NELFCD-AID 195 bp overlap

ChIP DLD-1_NELFCD-AID GSE144786.SUPT5H.DLD-1_NELFCD-AID 120 bp overlap

ChIP DLD-1_NELFCD-AID_treated GSE144786.SUPT5H.DLD-1_NELFCD-AID_treated 118 bp overlap

ChIP HCT-116_DMSO GSE138548.SUPT5H.HCT-116_DMSO 346 bp overlap

ChIP U2OS_siCtrl GSE115365.SUPT5H.U2OS_siCtrl 104 bp overlap

TAL1 3 datasets

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 174 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 188 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 145 bp overlap

TFAP4 1 dataset

ChIP HepG2 ENCFF030SRU 371 bp overlap

TGIF1 1 dataset

Motif DE_72h DE_72h-TGIF1_MA0796.1 12 bp overlap

TGIF2 1 dataset

Motif DE_72h DE_72h-TGIF2_MA0797.1 12 bp overlap

TGIF2LX 1 dataset

Motif DE_72h DE_72h-TGIF2LX_MA1571.1 12 bp overlap

TGIF2LY 1 dataset

Motif DE_72h DE_72h-TGIF2LY_MA1572.1 12 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 154 bp overlap

Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap

ChIP Huh-7 GSE97411.YY1.Huh-7 267 bp overlap

ZBTB21 2 datasets

ChIP HEK293 ENCFF509WYZ 421 bp overlap

ChIP HEK293 ENCSR321MSF.ZBTB21.HEK293 310 bp overlap

ZBTB32 1 dataset

Motif DE_72h DE_72h-ZBTB32_MA1580.1 10 bp overlap

ZBTB33 4 datasets

ChIP HepG2 ENCFF339WCT 257 bp overlap

ChIP HepG2 ENCFF778UKV 263 bp overlap

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 364 bp overlap

ChIP K562 ENCFF875HLX 162 bp overlap

ZBTB38 1 dataset

ChIP HepG2 ENCFF875UQX 521 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ChIP HEK293 ENCSR417VWF.ZEB2.HEK293 290 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 521 bp overlap

ChIP HEK293 ENCFF033NQQ 471 bp overlap

ZNF148 1 dataset

Motif DE_72h DE_72h-ZNF148_MA1653.2 10 bp overlap

ZNF189 1 dataset

ChIP HEK293 ENCSR163RYW.ZNF189.HEK293 361 bp overlap

ZNF274 1 dataset

ChIP Hep-G2 ENCSR871VNN.ZNF274.Hep-G2 184 bp overlap

ZNF280B 1 dataset

ChIP HepG2 ENCFF084BYB 342 bp overlap

ZNF281 1 dataset

Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap

ZNF366 1 dataset

ChIP HEK293 ENCSR106EBH.ZNF366.HEK293 507 bp overlap

ZNF449 2 datasets

Motif DE_72h DE_72h-ZNF449_MA1656.2 10 bp overlap

ChIP HEK293 ENCSR738SLS.ZNF449.HEK293 452 bp overlap

ZNF629 2 datasets

ChIP HEK293 ENCFF096ELQ 317 bp overlap

ChIP HEK293 ENCSR351NON.ZNF629.HEK293 435 bp overlap

ZNF667 1 dataset

Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap