This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for MOGS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOGS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOGS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,178,147–74,179,324 | 286.5 kb | Distal (>10kb) Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 277.1 kb | Distal (>10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 266.8 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:74,261,293–74,261,813 | 203.7 kb | Distal (>10kb) Multiome | 184 | |
| chr2:74,374,253–74,375,246 | 90.6 kb | Distal (>10kb) Multiome | 158 | |
| chr2:74,379,653–74,380,438 | 85.3 kb | Distal (>10kb) Multiome | 229 | |
| chr2:74,391,129–74,392,484 | 73.4 kb | Distal (>10kb) Multiome | 876 | |
| chr2:74,421,273–74,422,464 | 43.7 kb | Distal (>10kb) Multiome | 756 | |
| chr2:74,426,172–74,426,842 | 38.8 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,440,246–74,442,723 | 23.2 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:74,454,612–74,455,413 | 10.4 kb | Distal (>10kb) Multiome | 982 | |
| chr2:74,457,177–74,459,169 | 7.1 kb | Proximal (<10kb) Multiome | 934 | |
| chr2:74,461,447–74,461,655 | 3.7 kb | Proximal (<10kb) | 172 | |
| chr2:74,464,912–74,465,776 | 20 bp | At TSS Multiome | 842 | |
| chr2:74,472,106–74,473,059 | 7.3 kb | Proximal (<10kb) Multiome | 1071 | |
| chr2:74,481,955–74,483,673 | 17.8 kb | Distal (>10kb) Multiome | 1031 | |
| chr2:74,497,707–74,500,027 | 34.1 kb | Distal (>10kb) Multiome | 553 | |
| chr2:74,502,724–74,504,160 | 37.9 kb | Distal (>10kb) Multiome | 816 | |
| chr2:74,506,905–74,508,524 | 42.3 kb | Distal (>10kb) Multiome | 1063 | |
| chr2:74,515,477–74,516,725 | 51.0 kb | Distal (>10kb) Multiome | 262 | |
| chr2:74,529,210–74,530,815 | 64.5 kb | Distal (>10kb) Multiome | 988 | |
| chr2:74,548,706–74,549,795 | 84.1 kb | Distal (>10kb) Multiome | 625 | |
| chr2:74,553,035–74,555,636 | 89.2 kb | Distal (>10kb) Multiome | 768 | |
| chr2:74,647,804–74,648,489 | 182.9 kb | Distal (>10kb) Multiome | 232 | |
| chr2:74,653,808–74,654,908 | 188.9 kb | Distal (>10kb) Multiome | 658 | |
| chr2:74,715,073–74,715,890 | 250.0 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the MOGS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.