This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC4A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC4A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC4A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,119,987–74,120,643 | 213.8 kb | Distal (>10kb) Multiome | 969 | |
| chr2:74,147,573–74,148,843 | 186.2 kb | Distal (>10kb) Multiome | 884 | |
| chr2:74,178,147–74,179,324 | 155.3 kb | Distal (>10kb) Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 146.0 kb | Distal (>10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 135.7 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:74,261,293–74,261,813 | 72.6 kb | Distal (>10kb) Multiome | 184 | |
| chr2:74,334,940–74,335,139 | 747 bp | At TSS | 163 | |
| chr2:74,374,253–74,375,246 | 40.5 kb | Distal (>10kb) Multiome | 158 | |
| chr2:74,379,653–74,380,438 | 45.9 kb | Distal (>10kb) Multiome | 229 | |
| chr2:74,391,129–74,392,484 | 57.7 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr2:74,421,273–74,422,464 | 87.5 kb | Distal (>10kb) Multiome | 756 | |
| chr2:74,426,172–74,426,842 | 92.4 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,440,246–74,442,723 | 108.0 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:74,454,612–74,455,413 | 120.8 kb | Distal (>10kb) Multiome | 982 | |
| chr2:74,457,177–74,459,169 | 124.1 kb | Distal (>10kb) Multiome | 934 | |
| chr2:74,464,912–74,465,776 | 131.2 kb | Distal (>10kb) Multiome | 842 | |
| chr2:74,472,106–74,473,059 | 138.5 kb | Distal (>10kb) Multiome | 1071 | |
| chr2:74,481,955–74,483,673 | 149.0 kb | Distal (>10kb) Multiome | 1031 | |
| chr2:74,497,707–74,500,027 | 165.3 kb | Distal (>10kb) Multiome | 553 | |
| chr2:74,502,724–74,504,160 | 169.1 kb | Distal (>10kb) Multiome | 816 | |
| chr2:74,506,905–74,508,524 | 173.5 kb | Distal (>10kb) Multiome | 1063 | |
| chr2:74,515,477–74,516,725 | 182.2 kb | Distal (>10kb) Multiome | 262 | |
| chr2:74,529,210–74,530,815 | 195.6 kb | Distal (>10kb) Multiome | 988 | |
| chr2:74,548,706–74,549,795 | 215.3 kb | Distal (>10kb) Multiome | 625 | |
| chr2:74,553,035–74,555,636 | 220.3 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the SLC4A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.