NRL
neural retina leucine zipper | D14S46E, NRL-MAF, RP27

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]

Biological processes 29 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)leucine zipper domain binding (GO:0043522)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)promoter-specific chromatin binding (GO:1990841)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)retinal rod cell development (GO:0046548)sequence-specific double-stranded DNA binding (GO:1990837)visual perception (GO:0007601)
Expression (TPM)
NRL — as a Regulated Gene

TFs regulating NRL 0 TFs

Transcription factors with Perturb-seq knockdown data for NRL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NRL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:23,910,478–23,911,853 204.1 kb Distal (>10kb) Multiome 310
chr14:23,953,479–23,954,293 161.2 kb Distal (>10kb) Multiome 897
chr14:23,988,469–23,989,172 126.1 kb Distal (>10kb) Multiome 439
chr14:24,036,218–24,036,993 78.4 kb Distal (>10kb) Multiome 627
chr14:24,051,239–24,052,875 62.4 kb Distal (>10kb) Multiome 821
chr14:24,080,914–24,082,038 33.5 kb Distal (>10kb) Multiome 706
chr14:24,086,635–24,086,899 4.7 kb Proximal (<10kb) 39
chr14:24,090,412–24,090,855 8.5 kb Proximal (<10kb) 461
chr14:24,093,491–24,095,115 20.8 kb Distal (>10kb) Multiome 990
chr14:24,108,868–24,109,078 5.9 kb Proximal (<10kb) 542
chr14:24,113,681–24,115,917 8 bp At TSS Multiome 1166
chr14:24,135,549–24,136,884 21.1 kb Distal (>10kb) Multiome 778
chr14:24,140,526–24,142,331 26.7 kb Distal (>10kb) Multiome 1034
chr14:24,146,204–24,148,108 32.4 kb Distal (>10kb) Multiome 918
chr14:24,160,877–24,161,762 46.3 kb Distal (>10kb) Multiome 970
chr14:24,171,489–24,172,698 56.9 kb Distal (>10kb) Multiome 365
chr14:24,188,229–24,189,111 73.8 kb Distal (>10kb) Multiome 1074
chr14:24,195,072–24,196,365 80.6 kb Distal (>10kb) Multiome 1059
chr14:24,212,871–24,213,884 98.4 kb Distal (>10kb) Multiome 1036
chr14:24,215,523–24,216,241 101.0 kb Distal (>10kb) Multiome 955
chr14:24,231,706–24,233,147 117.6 kb Distal (>10kb) Multiome 1027
chr14:24,241,845–24,243,572 127.6 kb Distal (>10kb) Multiome 1077
chr14:24,270,770–24,271,924 156.5 kb Distal (>10kb) Multiome 1089
chr14:24,299,120–24,300,273 184.8 kb Distal (>10kb) Multiome 892
chr14:24,315,948–24,316,753 201.4 kb Distal (>10kb) Multiome 736
chr14:24,332,251–24,333,127 217.6 kb Distal (>10kb) Multiome 740
chr14:24,366,594–24,369,358 254.1 kb Distal (>10kb) Multiome 921
chr14:24,398,424–24,399,423 283.9 kb Distal (>10kb) Multiome 354

Genome Browser

Genomic view of the NRL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:23,900,478 – 24,409,423
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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